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Alli Diet Pills Review (UPDATED 2022): Does Alli Really Work?

The FDA's only over-the-counter diet pill.

Top Rated Diet Pills of 2022
What is it?

Alli is a weight loss pill intended to help people burn one pound of fat, for every 2 pounds lost through exercise. It’s an over the counter medication made to help reduce about 25% of the fat one eats.

It’s only available for people 18 and older, and for those who would be considered obese with a BMI of 25 or more. You also have to introduce a low-calorie, low-fat diet, and you have to make sure to take Alli alongside fats in your meals. The intended purpose of Alli is to remove some fat calories from your diet, by not having it digested, and instead being passed through one’s stool. So is this really an effective weight loss pill? What kinds of weight loss effects are possible? Featured in this Alli review is all the information needed to make an informed decision.

Overall the best weight loss pill we’ve reviewed this year is Sletrokor. This natural supplement combines plant based extracts which can assist fat loss in multiple ways. We’ve provided more information about Sletrokor including testimonials in the link here.

Do You Know the Best Weight Loss Pills of 2022?

Alli Ingredients and Side Effects



FD&C Blue No. 2

Edible Ink


Iron Oxide

Microcrystalline Cellulose


Sodium Lauryl Sulfate

Sodium Starch Glycolate


Titanium Dioxide


Orlistat: The sole key active ingredient in Alli. It’s used to help reduce the absorption of some fats, by having them removed by bowel movements.

You are advised to skip dosing these pills if you have a meal with no fats. It’s also advised to get no more than 30% of your calories from fat to make good use of this ingredient. Both Drugs.com and the official website for Alli confirm:

“Orlistat can make it harder for your body to absorb fat-soluble vitamins”

“may recommend that you take vitamin and mineral supplements while you are taking this medication”

This can reduce the intake of vitamins A, D, E, and K. When using this pill, it’s important to watch out for signs of vitamin and mineral deficiency. This can potentially lead to issues such as:

  • Brittle nails and dull looking hear.
  • Extreme fatigue.
  • Vision problems.
  • Mood swings and symptoms of depression.
  • Reduced muscle mass and weakness in the limbs.
  • Blindness.
  • Increased risk for disease.

Orlistat itself has also been shown to potentially cause side effects that include:

  • Blood in the urine.
  • Severe lower back pain.
  • Kidney problems including little to no urination.
  • Liver issues that may cause nausea, itching, loss of appetite, dark urine, fatigue, and yellowing of the skin and eyes.
  • Oily and or fatty stools.
  • Gas and oily discharge.
  • Stomach pain, increased bathroom usage, and rectal pain.
  • Inability to control your bowel movements.
  • Several other side effects

There are also other side effects that if experienced, it’s advised to seek immediate medical help. This can be a sign of serious health problems that can be potentially life threatening if not treated. Compiled in this link are the year’s best weight loss pills.

The official website does list some possible side effects, but a list on Drugs.com features all the possible issues people have experienced.

A clinical study of this ingredient showed very poor weight loss benefits.  The Cochrane Metabolic and Endocrine Disorders Group ran a study showing the effects of the active ingredient when used for over a year:

“compared to placebo, Orlistat reduced weight by 2.9 kg”

2.9 kg is 6.39 pounds. So people lost around 1.87 pounds each month. This is significantly less weight loss than what other supplements can provide. You also have to make sure to consider all the possible side effects, as well as reduce your calories and increase exercise.

The company claims that you can lose around 5% of your total body fat if taken according to their demands, but this still isn’t very much. The added diet and exercise is likely a major part of why there’s weight loss.

FD&C Blue No. 2: Synthetic food coloring added to help provide a blue color. It has no nutritional value, and is only added to make these pills appear blue. Rats given this ingredient were subject to:

“statistically significant increases in brain cancer”

This is according to a study by the Center for Science in the Public Interest.  They also advise that this ingredient should be banned, since it has no nutritional value. It’s also believed that this ingredient may cause hyperactivity as well.

Sodium Lauryl Sulfate: A detergent and foaming agent that may cause skin and eye irritation.

Sodium Starch Glycolate: White powder added to help a pill dissolve and absorb better. It can be extracted from common allergens like wheat and corn. Those allergic or sensitive to these ingredients won’t know which is added, since manufacturers aren’t required to list what extracts are used.

This top 10 list offers a brief outline of the best weight loss pills.

EDITOR’S TIP: Combine this supplement with a proven fat burner such as Sletrokor for better results.

Alli Quality of Ingredients

10 of the 11 ingredients are inactive, meaning they have no weight loss purpose.

The only truly beneficial ingredient is Orlistat, and its results on long term weight loss have been poor. You also have to make sure to take it alongside fats, so people who don’t eat much dietary fats wouldn’t see much improvement.

Clinical studies have shown that it may lead to serious side effects, of which there are many. Other studies have revealed that its weight loss effects are poor. Just over a pound of weight loss is possible each month, which isn’t much. This also comes at the addition of added diet and exercise, as well as special intake considerations, as not all people are advised to take this weight loss pill.

You also have to watch out for fat soluble vitamin loss, which may require extra supplementation with multivitamins.

To get the best weight loss results possible, we advise looking at the top 10 weight loss pills.

The Price and Quality of Alli

Alli is available for purchase in store and in online retail stores. One 40 day supply sells for $69.99 on Amazon.com. So you’re essentially paying $1.74 per pill.

Most of what’s inside this pill has no weight loss effect. It’s mostly made up of food coloring, pill stabilizers, and additives to ease digestion.

The sole active ingredient has been shown to help reduce dietary fats, but its possibility for side effects and vitamin and mineral loss. Also, the weight loss benefits have been incredibly poor, and as you’ll see in the “Customer Opinions of Alli” section, it’s not well reviewed by users.

The year’s best weight loss pills have been carefully ranked in the top 10 list here.

Business of Alli

Alli is owned by the pharmaceutical company GlaxoSmithKline; their US division can be reached below:

Phone Number: (800) 671-2554

Email: [email protected]

No returns are offered on Alli.

The makers have also been the subject of controversy over marketing and illegal actions.  They also were subject to the biggest fine ever imposed on a drug company. The Department of Justice adds:

“Unlawful promotion of certain prescription drugs, its failure to report safety data, and its civil liability for alleged false price reporting”

“largest health care fraud settlement in US history”

They hid information about possible side effects, and they manipulated prices for several of their drugs.

In 2022, they also recalled Alli after fears of contamination.  The FDA adds:

“the company believes some packages of the product were tampered with”

It’s unknown how this could have happened, but they voluntarily recalled all batches of Alli in the US.

For appetite suppression and lasting fat loss we recommend the years best weight loss pills.

EDITOR’S TIP: For the best results, our experts recommend using weight loss pills for at least 3 months. Save your money by buying a few bottles at once.

Customer Opinions of Alli

Several customer reviews are available online. Here’s what a few have experienced:

“hate so much that I paid for a product that did absolutely nothing”

“exercised as I did before, failed to lose any weight”

“It was disgusting and uncontrollable”

“Does not work at all”

Side effects were often listed, and they ranged from loose and oily stools, flatulence, increased bathroom usage, and sudden unexpected stools. A few people mentioned they couldn’t be far away from a bathroom, as they would suddenly get the urge to have to go immedietly.

A lack of weight loss was also listed as a problem. Currently 571 reviews on Amazon.com confirm the lack of beneficial effects. Many struggled to see any weight loss even with proper diet and exercise.

There was often concern that the new batches of Alli just aren’t as good, and that there’s a lack of any noticeable change.

Review the year’s best weight loss pills which were favorited by customers by clicking here.

Conclusion - Does Alli Work?

When considering weight loss pills like Alli, it’s important to look at clinical studies and customer opinions. Many users who tried Alli failed to see any change, and many severe side effects have also been listed. Though Alli can help reduce some fat intake, it only works to reduce fat, and it has no metabolism boosting or other calorie burning effects. So sugar and carbohydrates won’t be reduced.

Also, the possibility for loss of fat soluble vitamins might require extra supplementation. A better solution is available that has only natural ingredients, no laxative like side effects, and great customer reviews. The very best option of 2022 is the all-natural Sletrokor.

It doesn’t require a special diet, and you can rest assured this supplement won’t have laxative like side effects. Customers have also raved about the beneficial and long lasting weight loss effects. You can find these testimonials on their official website, with people leaving nothing but positive weight loss results.

Sletrokor is even backed by a reputable company that produces their formula in a FDA approved facility. Read testimonials, the ingredients list, and see what made Sletrokor our top weight loss pill by clicking here

How Does Alli Compare?
  • Product Name
  • User Rating
  • Has Good Appetite Suppressant
  • Has Only Natural Components
  • Contains No Coffee
  • Alli
  • 31 /100
  • .
  • .

> Leave Feedback

User Feedback

(Page 13 of 20, 389 total comments)

This pill is unnecessary

This pill doesn't do anything except train you...like you're a dog. How? Because if you eat healthy you'll be fine, but if you cheat you'll pay the price in the form of leaking an oily, smelly fluid out your bum. The pill itself does not make you lose weight, YOU eating healthier does; the pill just lets you know when you've been bad...which you could've discovered on your own without paying $50 and sitting on a toilet all day.

posted Aug 19th, 2008 9:06 am


Started on Alli with my doctors blessing - she actually gave me a months supply - yes, you better either not take it if your going out for the night and having a regular meal - make sure you have panties on:) otherwise - no problem - eat right - like WW plan and stay clear of fats.. or you'll be staining more than your panties... still have not loss any pounds - but I've only been on it for 2 weeks.., hope this works.

posted Aug 14th, 2008 10:04 am

tonya n tally

I am starting alli today. I've taken a product called renue by suddenly slim and has the same effects as alli with slower results. I will keep you posted on my results

posted Aug 11th, 2008 11:36 am


i didnt like alli they made me so sick to my tummy its not funny so i just stopped taking them i dont recremened them to anyone

posted Aug 4th, 2008 9:51 am

Dave Agresti

Tonight, July 31st, I first learned about Alli, the new diet pill. I never heard of it before so it caught my attention. In the commercial on CNN it was said that "millions of people have lost weight" using Alli. If it's so new, how could that many people report success? I would consider that lying to the public. Shouldn't CNN (and other stations running this commercial) pull the plug on this product? I'd like proof of the millions if it does exist.

posted Aug 1st, 2008 8:51 am


I used alli for a year. Initially lost 10 lbs but alli no longer works anymore. don't know if this is universal or just me. didn't change a thing. just stopped working.

posted Jul 29th, 2008 8:34 am

Marla 07/19/08

Hi Everyone My name is Marla. I bought the alli starter pack today and will be trying out tomorrow I am going to post a weekly update to let everyone knoe how it goes as I think most people (like myself ) read reviews. Just a little background I am probably not the typical person on here and not looking for the miracle answer. To be honest I am not overweight. I know you must be thinking why would someone not overweight take alli well for me it is to assist in a lifestyle change. I am a 29 year old mom..I am 5'5 and I weigh 131lbs. Sounds preety good huh ,,Well its not I eat 3 fast food meals a day and my body fat percentage is 36%. Thats right 36% which puts me in the category for high risk for a heart attack. Its not always about "looking skinny" however my dr. recommended alli to help me "adjust my lifestyle" and thats what I plan to do. Losing weight I guess is the bonus. Regardless if this pill ccan help me eat healthier and make a lifestyle change Im all for it. I will post weekly and let all know how it pans out.

posted Jul 22nd, 2008 11:26 am


I have lost three pounds in one week. I usually take 2 Alli a day with one semi-fattening meal. I have no side effects what so ever.

posted Jul 18th, 2008 3:55 pm



posted Jul 13th, 2008 9:09 am


I started on Alli in April of 2008. I was 201lbs, a size 14-15 and 5'8". It's now the middle of July, and I'm at 181 and a size 12. I hardly exercise and have a desk job. I hang out pretty close to the fat limit per meal. I have very few side effects; when I do, they're limited to oily discharge while going to the bathroom. Better there, than on my thighs.

posted Jul 12th, 2008 6:15 pm


Omgosh the side effects are very REAL. I had gas with oil spots. Think about having a bowel movement with all fat coming out and then your rear feels like you put butter on it. Yuck I know but when I ate a little fat it did not happen that often but one day the office had a party and I had some higher fat food I had to go home a change my pants. So when they say you have to stay on a low fat diet they are not kidding. If you cheat you will not like what happens. I only been taking it for a week so no weight change. But i not going to take it anymore because it not worth the side effects i had.

posted Jul 12th, 2008 2:36 pm


I had thought about bying Alli, but as I read all the stories, I got scared. One day I finally did it. I've been on it for 3 weeks. I have not yet had a side affect and have lost 2 lbs a week. I am also on a very low fat diet and jog 3 miles 3x a week.

posted Jul 11th, 2008 3:26 pm


Kim, I've been doing the weight watcher meals, and the recipes in the alli cook books, and the weight is coming off for me

posted Jul 5th, 2008 10:06 am


hi guys, ive been taking xenical for 2 days now and have used the toilet once and it seemed normal. im worried about how much fat im eating as i really dont have a clue . ive bought this drug in a foriegn country as i cant see a doctor here .. i was wondering if anyone could help me find a low fat diet plan that will work with xenical as i cant find anything on the net. Im so desperate to loose weight im 93 kg at 5.4 and its really getting me down . Thank you :)

posted Jul 4th, 2008 9:13 am


I havent seen any one mention that Alli does help people who have problems with being regular. My weight came from not being able to go. Laxatives are out of the question and high fiber diet just made it worse for me. I started Alli YES to help lose weight but it has done more than that for me. I havn't been regular since I was a baby. Alli helps me to go EVERY day with out straning. I guess the fat helps lube up my digestive track making it WAY easier to go. I lost 15 lbs with Alli. I do watch what I eat and do alot of house work to act as my excersice. When I don't take Alli I am back to NOT being able to go at all or very little. It's nice to have something that doesn't HARM your digestive track. I hope they never stop making it. As far as side effects just make sure you DON'T eat those foods that cause nasty leakage. Simple as that.

posted Jul 1st, 2008 7:54 am


June 30, 200b, I am planning to statrt this Diet, are there any new updates?

posted Jun 30th, 2008 9:56 am


i dont know i just started this Alli crap and i didnt think the first few days anything was gonna happen 2 me and WHOA it just hit me, AND my undergarmets.....i was so upset and still am... i just stopped taking it now.....if you can handle wearing diapers and locking yourself indoors all day then go for Alli but otherwise this is just not for me......i am absolutely disgusted!!

posted Jun 29th, 2008 5:50 pm


alli seems to work, but i do watch fat intake . lost 5 pounds in 2 weeks. i have forgotten to take pill and then took after i ate. does alli still work the same way then ???

posted Jun 29th, 2008 5:47 pm


I've been taking Alli for 3 days now and I haven't seen any weight loss yet( I do feel less bloated). I exercise 3-4 times a week- every week. My problem was I just eat food that's really, really bad for me. Although, I haven't seen any weight loss yet, I do like the pill. In 3 days, I've learned that even food that I thought was reasonably good for me.... is actually not- And the dreaded TE's are proof. That oily discharge is no joke. But I'm learning how to eat better. Even if you take Alli just to help you learn what to eat and what not to eat, I believe it's worth it.

posted Jun 27th, 2008 8:10 am


I've been on alli for 2 weeks and i have lost 6lbs! before using alli i lost 11 lbs so ive lost a total of 17lbs. I like alli because the treatment affects scare me away from eating fatty foods. I have had some treatment affects, but they were not bad at all. I go to the gym for an hour-an hour and a half 6 days a week and i eat around 1300 calories a day. Im loving it, i just hope it keeps working!

posted Jun 27th, 2008 8:10 am


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BACKGROUNDBACKGROUND Start the Diet Now Advertisement

Warning: Alli Linked To Liver Damage

The anticipation for a new diet pill is over as the FDA recently approved Alli (pronounced Al-eye). It's the weight loss newcomer that is quickly finding its place on drug store shelves. Alli is the first FDA-approved diet pill available without a prescription. Alli is actually a low-dose version of Xenical, a prescription drug that successfully assists obese individuals losing weight. Xenical is taken under a doctor's care while following a low-calorie, low-fat diet. Alli has the same active ingredient (Orlistat), but in a much lower dosage, and is available without the prescription.

Alli can help you lose a few pounds more than just dieting and exercise alone. It works by suppressing the body's ability to absorb fat in the intestines. By reducing fat, you reduce calories. When the body is unable to absorb these fats they become undigested waste.

Alli works best when it is used in conjunction with a low-calorie, low-fat diet and a regular exercise program. But since sticking to a reduced-calorie diet is tough and since certain foods need to be avoided while using the diet pill, Alli has partnered with eDiets, a meal delivery service that delivers Alli-specific meals to your door every week.

While some may view Alli as a controversial solution to weight loss, the manufacturers of this product have gone to great lengths to offer a comprehensive program to its users in order to make weight loss as easy and approachable as possible.

Although studies on the amount of weight loss you can lose with Alli are limited, you can expect to lose three to five pounds more than just relying on diet and exercise alone.

Do You Know the Best Diet Pills of 2022?

  • May help to jump start a weight loss program
  • Comprehensive website that offers support, food journals, calorie counters, meal plans and shopping lists
  • Partnership with eDiets makes eating and meal planning simple and convenient
  • The only over-the-counter diet pill with FDA approval
  • Low-dose version of effective prescription diet pill
  • Some think it shouldn’t be sold without a prescription
  • Not a long-term solution to weight loss
  • Uncomfortable side effects
  • Must be very careful to not exceed the maximum fat gram requirement with each meal
  • Weight loss affects are modest
  • Meal delivery services don't teach you how to consume and prepare your own calorie and portion-controlled meals

Alli contains 60 mg of Orlistat.


Alli is a 60 mg tablet taken three times a day with meals that should not exceed 15 mg of fat.


A low-fat and low-calorie diet must be followed while taking Alli. Since the success of Alli depends so largely on what you eat, how much you eat and when you eat, you have two choices for designing the most effective meal plan for your weight loss needs:

  • You could consult with your physician or a registered dietitian to design a well-laid out diet and exercise plan.
  • You could sign up for Alli's partner eDiets, a meal delivery service that creates special Alli-approved meals and delivers them to your door each week.

With the eDiets plan, you eat three meals a day plus snack and desserts. Menus can be personalized to reflect your tastes and preferences and you also have access to a registered dietitian, an online community of other Alli dieters and fitness and exercise support.

Since the fat content of each meal must be closely monitored while using Alli (no more than 15 mg each day), eDiets special Alli-approved meals meet these requirements so that your risk of side effects is kept to a minimum.

The eDiets menu includes a wide variety of delicious meals, including:

  • Maple Apple Oatmeal
  • Denver Style Potato Skillet with Turkey Ham
  • Rosemary Pork with Brown Rice
  • Oven Roasted Turkey with Savory Sweet Potatoes and Mixed Garden Vegetables
  • Blackened Chicken served with Seasoned Spicy Brown Rice
  • Peach Cobbler
  • Sugar-free Pudding

Irrespective of which meal plan you follow, since Alli inhibits the absorption of fat-soluble vitamins, it is important to take a daily supplement that includes Vitamins A, D and E.

In addition, for the best results, a regular exercise program should also be followed that includes 30 minutes of exercise on most days of the week. If you decide to sign-up with eDiets meal delivery service, you have access to a live fitness trainer to help you customize an exercise plan to compliment your weight loss needs.


Many people have seen positive results with Alli. However, those considering taking Alli should note that side effects can include gas, and uncontrolled urination and bowel movements, especially when not following the guidelines prescribed by Alli.

Alli is not a magic pill to lose weight, but its special partnership with eDiets, a meal delivery service, makes eating and meal planning simple and convenient.

Do keep in mind that the effects of taking Alli in comparison to just dieting and exercising alone are just the difference of a few pounds. It is necessary that you consult with your medical practitioner before taking Alli.

Common MisspellingsCommon Misspellings

Alle, Ally, Alli Diet, Alli Pill, Alli Diet Pill, Allu, alli.com

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