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Alli Diet Pills Review (UPDATED 2022): Does Alli Really Work?

The FDA's only over-the-counter diet pill.

Top Rated Diet Pills of 2022
What is it?

Alli is a weight loss pill intended to help people burn one pound of fat, for every 2 pounds lost through exercise. It’s an over the counter medication made to help reduce about 25% of the fat one eats.

It’s only available for people 18 and older, and for those who would be considered obese with a BMI of 25 or more. You also have to introduce a low-calorie, low-fat diet, and you have to make sure to take Alli alongside fats in your meals. The intended purpose of Alli is to remove some fat calories from your diet, by not having it digested, and instead being passed through one’s stool. So is this really an effective weight loss pill? What kinds of weight loss effects are possible? Featured in this Alli review is all the information needed to make an informed decision.

Overall the best weight loss pill we’ve reviewed this year is Sletrokor. This natural supplement combines plant based extracts which can assist fat loss in multiple ways. We’ve provided more information about Sletrokor including testimonials in the link here.

Do You Know the Best Weight Loss Pills of 2022?

Alli Ingredients and Side Effects



FD&C Blue No. 2

Edible Ink


Iron Oxide

Microcrystalline Cellulose


Sodium Lauryl Sulfate

Sodium Starch Glycolate


Titanium Dioxide


Orlistat: The sole key active ingredient in Alli. It’s used to help reduce the absorption of some fats, by having them removed by bowel movements.

You are advised to skip dosing these pills if you have a meal with no fats. It’s also advised to get no more than 30% of your calories from fat to make good use of this ingredient. Both Drugs.com and the official website for Alli confirm:

“Orlistat can make it harder for your body to absorb fat-soluble vitamins”

“may recommend that you take vitamin and mineral supplements while you are taking this medication”

This can reduce the intake of vitamins A, D, E, and K. When using this pill, it’s important to watch out for signs of vitamin and mineral deficiency. This can potentially lead to issues such as:

  • Brittle nails and dull looking hear.
  • Extreme fatigue.
  • Vision problems.
  • Mood swings and symptoms of depression.
  • Reduced muscle mass and weakness in the limbs.
  • Blindness.
  • Increased risk for disease.

Orlistat itself has also been shown to potentially cause side effects that include:

  • Blood in the urine.
  • Severe lower back pain.
  • Kidney problems including little to no urination.
  • Liver issues that may cause nausea, itching, loss of appetite, dark urine, fatigue, and yellowing of the skin and eyes.
  • Oily and or fatty stools.
  • Gas and oily discharge.
  • Stomach pain, increased bathroom usage, and rectal pain.
  • Inability to control your bowel movements.
  • Several other side effects

There are also other side effects that if experienced, it’s advised to seek immediate medical help. This can be a sign of serious health problems that can be potentially life threatening if not treated. Compiled in this link are the year’s best weight loss pills.

The official website does list some possible side effects, but a list on Drugs.com features all the possible issues people have experienced.

A clinical study of this ingredient showed very poor weight loss benefits.  The Cochrane Metabolic and Endocrine Disorders Group ran a study showing the effects of the active ingredient when used for over a year:

“compared to placebo, Orlistat reduced weight by 2.9 kg”

2.9 kg is 6.39 pounds. So people lost around 1.87 pounds each month. This is significantly less weight loss than what other supplements can provide. You also have to make sure to consider all the possible side effects, as well as reduce your calories and increase exercise.

The company claims that you can lose around 5% of your total body fat if taken according to their demands, but this still isn’t very much. The added diet and exercise is likely a major part of why there’s weight loss.

FD&C Blue No. 2: Synthetic food coloring added to help provide a blue color. It has no nutritional value, and is only added to make these pills appear blue. Rats given this ingredient were subject to:

“statistically significant increases in brain cancer”

This is according to a study by the Center for Science in the Public Interest.  They also advise that this ingredient should be banned, since it has no nutritional value. It’s also believed that this ingredient may cause hyperactivity as well.

Sodium Lauryl Sulfate: A detergent and foaming agent that may cause skin and eye irritation.

Sodium Starch Glycolate: White powder added to help a pill dissolve and absorb better. It can be extracted from common allergens like wheat and corn. Those allergic or sensitive to these ingredients won’t know which is added, since manufacturers aren’t required to list what extracts are used.

This top 10 list offers a brief outline of the best weight loss pills.

EDITOR’S TIP: Combine this supplement with a proven fat burner such as Sletrokor for better results.

Alli Quality of Ingredients

10 of the 11 ingredients are inactive, meaning they have no weight loss purpose.

The only truly beneficial ingredient is Orlistat, and its results on long term weight loss have been poor. You also have to make sure to take it alongside fats, so people who don’t eat much dietary fats wouldn’t see much improvement.

Clinical studies have shown that it may lead to serious side effects, of which there are many. Other studies have revealed that its weight loss effects are poor. Just over a pound of weight loss is possible each month, which isn’t much. This also comes at the addition of added diet and exercise, as well as special intake considerations, as not all people are advised to take this weight loss pill.

You also have to watch out for fat soluble vitamin loss, which may require extra supplementation with multivitamins.

To get the best weight loss results possible, we advise looking at the top 10 weight loss pills.

The Price and Quality of Alli

Alli is available for purchase in store and in online retail stores. One 40 day supply sells for $69.99 on Amazon.com. So you’re essentially paying $1.74 per pill.

Most of what’s inside this pill has no weight loss effect. It’s mostly made up of food coloring, pill stabilizers, and additives to ease digestion.

The sole active ingredient has been shown to help reduce dietary fats, but its possibility for side effects and vitamin and mineral loss. Also, the weight loss benefits have been incredibly poor, and as you’ll see in the “Customer Opinions of Alli” section, it’s not well reviewed by users.

The year’s best weight loss pills have been carefully ranked in the top 10 list here.

Business of Alli

Alli is owned by the pharmaceutical company GlaxoSmithKline; their US division can be reached below:

Phone Number: (800) 671-2554

Email: [email protected]

No returns are offered on Alli.

The makers have also been the subject of controversy over marketing and illegal actions.  They also were subject to the biggest fine ever imposed on a drug company. The Department of Justice adds:

“Unlawful promotion of certain prescription drugs, its failure to report safety data, and its civil liability for alleged false price reporting”

“largest health care fraud settlement in US history”

They hid information about possible side effects, and they manipulated prices for several of their drugs.

In 2022, they also recalled Alli after fears of contamination.  The FDA adds:

“the company believes some packages of the product were tampered with”

It’s unknown how this could have happened, but they voluntarily recalled all batches of Alli in the US.

For appetite suppression and lasting fat loss we recommend the years best weight loss pills.

EDITOR’S TIP: For the best results, our experts recommend using weight loss pills for at least 3 months. Save your money by buying a few bottles at once.

Customer Opinions of Alli

Several customer reviews are available online. Here’s what a few have experienced:

“hate so much that I paid for a product that did absolutely nothing”

“exercised as I did before, failed to lose any weight”

“It was disgusting and uncontrollable”

“Does not work at all”

Side effects were often listed, and they ranged from loose and oily stools, flatulence, increased bathroom usage, and sudden unexpected stools. A few people mentioned they couldn’t be far away from a bathroom, as they would suddenly get the urge to have to go immedietly.

A lack of weight loss was also listed as a problem. Currently 571 reviews on Amazon.com confirm the lack of beneficial effects. Many struggled to see any weight loss even with proper diet and exercise.

There was often concern that the new batches of Alli just aren’t as good, and that there’s a lack of any noticeable change.

Review the year’s best weight loss pills which were favorited by customers by clicking here.

Conclusion - Does Alli Work?

When considering weight loss pills like Alli, it’s important to look at clinical studies and customer opinions. Many users who tried Alli failed to see any change, and many severe side effects have also been listed. Though Alli can help reduce some fat intake, it only works to reduce fat, and it has no metabolism boosting or other calorie burning effects. So sugar and carbohydrates won’t be reduced.

Also, the possibility for loss of fat soluble vitamins might require extra supplementation. A better solution is available that has only natural ingredients, no laxative like side effects, and great customer reviews. The very best option of 2022 is the all-natural Sletrokor.

It doesn’t require a special diet, and you can rest assured this supplement won’t have laxative like side effects. Customers have also raved about the beneficial and long lasting weight loss effects. You can find these testimonials on their official website, with people leaving nothing but positive weight loss results.

Sletrokor is even backed by a reputable company that produces their formula in a FDA approved facility. Read testimonials, the ingredients list, and see what made Sletrokor our top weight loss pill by clicking here

How Does Alli Compare?
  • Product Name
  • User Rating
  • Has Good Appetite Suppressant
  • Has Only Natural Components
  • Contains No Coffee
  • Alli
  • 31 /100
  • .
  • .

> Leave Feedback

User Feedback

(Page 16 of 20, 389 total comments)


Does anyone know, about the multivitamin, i read they said it is VERY important to be on a multivitamin, it says take before bed, but i am used to taking mine in the morning. Does it matter?

posted Mar 27th, 2008 2:20 pm


I am SO scared to try it!! I know I want to, but I'm just nervous about the side effects. My best friend tried it for one month, she didn't work-out, but she did change her diet and she lost 10 pounds. I'm thinking I want to do the same...except WITH working out. I want to lose a total of 50, but will settle for 20 if I can the first few months. I'm going to buy me a bottle and give it a go this weekend. It's 03/26/08 now, so, I will check back with my progress in one month! Wish me luck!

posted Mar 26th, 2008 2:47 pm


I am on my second week of taking Alli. I've already noticed that my pants are a little looser! I have had some of the side effects but just because I did cheat. When I eat health, everything is fine. If you follow the diet, you will see results as with anything. I think some of the people who are making the bad comment about Alli are people looking for a "quick" fix drug that will allow them to still eat whatever and however much they want.

posted Mar 17th, 2008 5:07 pm


I have been taking Alli for about three weeks and have lost almost 15 lbs. My goal weight is 165 and I am at 173 now. If you follow a low cal low fat diet you will loose weight. If follow weight watchers program with this pill you will loose major pounds. When you don't stick to Low Cal you WILL have side effects! This will help you to stick to it!

posted Mar 16th, 2008 6:37 pm


i am considering trying alli. however, sometimes you can't avoid a fatty meal when you need to go out for dinner etc. anyone just skipped a dose of the pill? and continued the next day? would that decrease any possible side effectS?

posted Mar 13th, 2008 10:20 am


I have started Alli on 3-8-08 and really havent noticed any harsh treatment affects, but i have noticed i am peeing alot, more, and cant hold it.. so when i gotta go i gotta go.. i dont check the scales i dont believe in those i no if my pants dont fit or my love handles are showing..lol.. either way i hope this works, but again i keep saying it does force you to change ur eating habits and with any diet, surgery, etc.. if you dont change your EATING HABITS" you will gain the weight back, this is gonna force u to eat right.. and then you will train urself to eat that way all the time.. but for now i follow my own diet, i look at the guide for some pointers..though..

posted Mar 12th, 2008 4:25 pm


I have been on alli for two weeks now, I work out 3 times a week, have reduced my fat intake and I have already lost 10 pounds. It does have side effects in the bowel area but as long as you eat right you will be okay. I am on my way to success and alli is helping.

posted Mar 11th, 2008 6:38 pm


Today I started to take alli, and I was wondering if I decide to take in 15-20 grams of fat all day instead of 35 grams, does this matter?? Should I take it if I skip ameal?

posted Mar 11th, 2008 1:17 pm

Dan Knows

Nanny or anyone else wondering if this product is for you. Don't waste your money on any diet products. Im not saying that they don't work, however the juice is not worth the squeeze. Follow a sensible diet plan, exercise and you will lose weight. The last thing you want is to develop a dependency on these products. I was 310 when I started my diet 6 months ago. I am now 205. Even with the plateau if you use logic you will lose weight. Burn more then you consume...

posted Mar 11th, 2008 10:20 am



posted Mar 11th, 2008 10:20 am


i have been taking this for two days and lord the side effects are bad! i mean i have been eating subway sandwiches with outh so much mustard on it and u still get bubbly, but i am eating only once a day and i snack on fruit so hopefully this will go well!

posted Mar 11th, 2008 10:20 am

claudia 3/08

i have taken it for only 2 days and yes i've noticed the side effects, you have to cut fat foods ..i noticed if i eat something that has 4g of fat i get the effects but hopefully it works for these 3 months!!

posted Mar 11th, 2008 10:20 am


Hopeless, can you give me an update on your weight loss success? I would like to lose 15 pounds by July or August and am considering Alli. I had thyroid surgery in September and have gained 10 so your updated comments will help

posted Mar 4th, 2008 2:43 pm


I took it for aout four months and lost about twenty pounds, without being moody, or any heart palpitations, it is a great product. I am planning to have a baby so I stopped, but I plan to be back on it....

posted Mar 3rd, 2008 8:02 am


I have been the alli pills for 3 weeks now.I feels its working a lost at least 5 pounds now.The biggest thing you have watch what you eat.It does somewhat cuts your appetite...By you adding a little exercise you come out with better results...Good Luck to everyone

posted Feb 29th, 2008 10:22 am


Well i have read all these comments and there seem to be more good then bad, i have always been scared of taking pills, i heard they can increse your heart rate and make you shaky. I sure hope Alli dosent do that. Today is 1/28/08, I plan to start on Sunday. I want to lose 35 pounds. I quiet smoking last month and have gained about 20 so i have to lose!!

posted Feb 28th, 2008 9:48 pm

Alli Works

I actually started tryin to lose weight for the first time 6 weeks ago. For the first three weeks, I did it on my own. I cut my Maintenance level of calories down to 1500 and I cut the fat down to 30 grams a day. I don't have time to babysit the gym, but I did work out for 30 minutes 2 times a week. Maybe I could have done more, but, nonetheless, I lost 4 pounds. This I did by myself, before I even bought Alli. I started Alli at the beginning of my second three week run, doing the EXACT same thing I did before except, now I was taking Alli. My three week run just finished two days ago and I've lost 6 pounds. It might not sound like much to most people, but I'm proud of it. It's not surgery, and it's something I can do without the pill. Alli just helps knock off more. I'm going to keep taking it until I reach my goal weight. I'm going to keep excercising and eating less, with or without Alli, but I think it's a great product.


I have been on Alli for about four weeks now. I eat a low fat diet and I have lost 15 lbs. I have bben told by the dietician on myalli.com that I am not eating enough fat per meal, I eat around 10 grams at the most, this is probably why I have not had any treatment effects. I do seem to have more gas because I am eating more vegetables and whole grains, but I now just take some gas-X with my meal and this helps. When I plan to go out to dinner and have a high fat meal, I just do not take the pill for that meal, so I do not have any issues.


I've been on Alli for 1 1/2 weeks. I've coupled it with a big reduction in fat intake and total calorie intake (although I haven't added in exercise yet). I've had no ill side effects except a tad of constipation. I've dropped 12 lbs!


i have been on Alli for about 4 weeks now and just love it. I have lost 18 lbs and hubby has lost a total of 26 lbs. We have yet to have any "TE" yet. How veer like with all diet choices if you are not smart about how to eat healthy after you have lost the amount of weight you want I am sure you will gain all your weight back and then some. I have lost over 200 lbs at one time but I still have the same 25 lbs to come back on because I get lazy and do not eat the way I should. this last regain of the weight was because of some meds I was taking and since the docs have finally got me on the right stuff I am able to lose again. Take it from someone who used to live on a diet if you are not willing to make this a life stlye change for your self then you will regain your weight. The way we ate before we lose are weight caused the weight gain in the first place why would you expect if you go back to that way of eating would you think you would not gain your weight back? It is just something to think about. But as far as Alli I am a beliver it works and I am proving that the info you have heard about it does work. as long as you follow a lower fat diet (Less then 30% fat) and exercise taking the pill you will lose weight. Some may lose it slower then others but you have to look at the whole picture and make sure it is a plan you can live with for the rest of your life and should you gain 5 lbs back or so you must be willing to get right back on the program and take it off. If you can do this then your weight loss will be a forever thing as long as you keep with it. Take it from someone who has keep off 180 lbs for over 20 yrs now.


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BACKGROUNDBACKGROUND Start the Diet Now Advertisement

Warning: Alli Linked To Liver Damage

The anticipation for a new diet pill is over as the FDA recently approved Alli (pronounced Al-eye). It's the weight loss newcomer that is quickly finding its place on drug store shelves. Alli is the first FDA-approved diet pill available without a prescription. Alli is actually a low-dose version of Xenical, a prescription drug that successfully assists obese individuals losing weight. Xenical is taken under a doctor's care while following a low-calorie, low-fat diet. Alli has the same active ingredient (Orlistat), but in a much lower dosage, and is available without the prescription.

Alli can help you lose a few pounds more than just dieting and exercise alone. It works by suppressing the body's ability to absorb fat in the intestines. By reducing fat, you reduce calories. When the body is unable to absorb these fats they become undigested waste.

Alli works best when it is used in conjunction with a low-calorie, low-fat diet and a regular exercise program. But since sticking to a reduced-calorie diet is tough and since certain foods need to be avoided while using the diet pill, Alli has partnered with eDiets, a meal delivery service that delivers Alli-specific meals to your door every week.

While some may view Alli as a controversial solution to weight loss, the manufacturers of this product have gone to great lengths to offer a comprehensive program to its users in order to make weight loss as easy and approachable as possible.

Although studies on the amount of weight loss you can lose with Alli are limited, you can expect to lose three to five pounds more than just relying on diet and exercise alone.

Do You Know the Best Diet Pills of 2022?

  • May help to jump start a weight loss program
  • Comprehensive website that offers support, food journals, calorie counters, meal plans and shopping lists
  • Partnership with eDiets makes eating and meal planning simple and convenient
  • The only over-the-counter diet pill with FDA approval
  • Low-dose version of effective prescription diet pill
  • Some think it shouldn’t be sold without a prescription
  • Not a long-term solution to weight loss
  • Uncomfortable side effects
  • Must be very careful to not exceed the maximum fat gram requirement with each meal
  • Weight loss affects are modest
  • Meal delivery services don't teach you how to consume and prepare your own calorie and portion-controlled meals

Alli contains 60 mg of Orlistat.


Alli is a 60 mg tablet taken three times a day with meals that should not exceed 15 mg of fat.


A low-fat and low-calorie diet must be followed while taking Alli. Since the success of Alli depends so largely on what you eat, how much you eat and when you eat, you have two choices for designing the most effective meal plan for your weight loss needs:

  • You could consult with your physician or a registered dietitian to design a well-laid out diet and exercise plan.
  • You could sign up for Alli's partner eDiets, a meal delivery service that creates special Alli-approved meals and delivers them to your door each week.

With the eDiets plan, you eat three meals a day plus snack and desserts. Menus can be personalized to reflect your tastes and preferences and you also have access to a registered dietitian, an online community of other Alli dieters and fitness and exercise support.

Since the fat content of each meal must be closely monitored while using Alli (no more than 15 mg each day), eDiets special Alli-approved meals meet these requirements so that your risk of side effects is kept to a minimum.

The eDiets menu includes a wide variety of delicious meals, including:

  • Maple Apple Oatmeal
  • Denver Style Potato Skillet with Turkey Ham
  • Rosemary Pork with Brown Rice
  • Oven Roasted Turkey with Savory Sweet Potatoes and Mixed Garden Vegetables
  • Blackened Chicken served with Seasoned Spicy Brown Rice
  • Peach Cobbler
  • Sugar-free Pudding

Irrespective of which meal plan you follow, since Alli inhibits the absorption of fat-soluble vitamins, it is important to take a daily supplement that includes Vitamins A, D and E.

In addition, for the best results, a regular exercise program should also be followed that includes 30 minutes of exercise on most days of the week. If you decide to sign-up with eDiets meal delivery service, you have access to a live fitness trainer to help you customize an exercise plan to compliment your weight loss needs.


Many people have seen positive results with Alli. However, those considering taking Alli should note that side effects can include gas, and uncontrolled urination and bowel movements, especially when not following the guidelines prescribed by Alli.

Alli is not a magic pill to lose weight, but its special partnership with eDiets, a meal delivery service, makes eating and meal planning simple and convenient.

Do keep in mind that the effects of taking Alli in comparison to just dieting and exercising alone are just the difference of a few pounds. It is necessary that you consult with your medical practitioner before taking Alli.

Common MisspellingsCommon Misspellings

Alle, Ally, Alli Diet, Alli Pill, Alli Diet Pill, Allu, alli.com

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