Replenex Review: Don’t Buy Before You Read This!

Expert rating: stars-icon     By Natalie K (Senior Reviewer) December 12, 2023       Advertising Disclosure

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What is it?

Replenex is a brand of joint health supplements that is recommended for weekend athletes, individuals with repetitive motion stress, and people looking to counteract the effects of aging. Their website claims that Replenex provides natural connective system support while also functioning as an anti-inflammatory and pain reducer. They have a variety of formulations to accommodate different needs, and their family of products comes in regular, extra strength, and in a pink lemonade drink mix form.

Our team of nutritional experts has performed a series of tests on the leading brands of joint health supplements, and the product that performed the best is called Flexitrinol. Flexitrinol was the most successful at increasing users’ range of motion and overall flexibility while at the same time decreasing their inflammation and pain levels. Click here to read more about the tests why Flexitrinol was so successful.

Replenex Ingredients and Side Effects
Vitamin C Manganese Chondroitin MSM Devil’s Claw
Ginger Chokeberry Angelica Gigas Turmeric Green Tea

 Vitamin C: One of the most basic chemicals in the human body and a vital component to overall health and wellness. There are no negative side effects associated with consuming normal quantities of vitamin C.

Manganese: An essential trace element that the body needs for metabolism and antioxidant function. Manganese is safe for human consumption when taken in reasonable doses.

Chondroitin: A popular chemical in many joint health supplements because of its ability to help reduce inflammation while also increasing synovial fluid (the viscous material that lubricates and cushions joints). Chondroitin is considered safe for human consumption and has no known serious side effects.

MSM: Short for methylsulfonylmethane, another additive that appears frequently in joint health blends. MSM is derived from green plants and is used as an anti-inflammatory agent. MSM is safe and there are no known side effects associated with its consumption.

Devil’s Claw: An herb with hook-shaped fruit that is used as an anti-inflammatory agent in traditional African medicine. There is very little data from western scientists about the effects of devil’s claw, however it has been used in the past to treat back pain and osteoarthritis. Doctors estimate that about 8% of people that take devil’s claw will get diarrhea, and other side effects could potentially include:

  • Nausea
  • Vomiting
  • Ringing in the ears
  • Headaches
  • Loss of appetite
  • Loss of senses
  • Menstrual problems

Ginger: Traditionally used as flavoring or scenting agent in food and household products, some cultures have also used ginger as a medicinal aid. It has mostly been applied in the treatment of stomach and digestive disorders such as motion sickness, morning sickness and intestinal gas. There is very little information about the actual biological effects of ginger, but some side effects that could possibly be associated with its consumption include:

  • Heartburn
  • Diarrhea
  • Skin irritation
  • Bleeding problems
  • Increased menstrual flow
  • Complications with diabetes

Chokeberry: A fad superfruit that is known for its high antioxidant levels and very sour taste. Chokeberries have not been widely studied so the extent of their medicinal value is unknown, as is whether or not there are any side effects associated with their consumption.

Angelica Gigas: Another herbal ingredient with little clinical data supporting its medicinal value. Some people have used angelica gigs in the treatment of heartburn, anorexia, and premature ejaculation. There has not been enough research done to say conclusively if there are any side effects associated with angelica gigas consumption or not.

Turmeric: Turmeric is similar to ginger in that it is generally known as a food additive, however some people have used it medicinally. Practitioners of the eastern medicinal school of thought known as Ayurveda have applied turmeric to cases of heartburn, jaundice, IBS, and it is also thought to have anti-inflammatory properties. Side effects that could be connected to turmeric consumption include:

  • Nausea
  • Dizziness
  • Diarrhea
  • Upset stomach
  • Abnormal heart rhythms

Green Tea: Traditionally consumed as a beverage with energy-giving properties and occasionally used medicinally by some cultures. Green tea is high in antioxidants and polyphenols and has been used to treat genital warts, depression, and inflammatory bowel disease. The only negative side effects related to green tea are due to its mild caffeine content, however there is not enough in Replenex that it should affect anyone except those with the most extreme caffeine sensitivities.

Click here to see our experts’ list of the most effective joint health supplements on the market.

Replenex Quality of Ingredients

It is difficult to know how effective Replenex may be for any given consumer. Its ingredients are a blend of basic, reliable joint health products like glucosamine, manganese, chondroitin, and MSM and a bunch of untested herbs that may or may not have medicinal value, such as turmeric, devil’s claw, and angelica gigas.

If those ingredients do have medicinal value it may or may not be related in any way to joint health, though many have shown indications of anti-inflammatory properties.

What’s more concerning is the lack of long-term data about daily consumption of these ingredients. There are no 5- or 10-year studies about the prolonged effects of exposure to these additives, which means the possibility of serious long-term health consequences cannot be ruled out.

Follow this link to see which joint health supplements performed the best in our team of experts’ clinical trials.

The Price and Quality of Replenex

The price of Replenex can be difficult to assess, mainly due to the membership-program of their manufacturer, Melaleuca. Melaleuca does not sell Replenex through their website, or even quote prices, to anyone that does not register for their program. Looking through other online sellers and second-hand supplement retailers, it seems that consumers should expect to pay somewhere in this range:

  • 1 90-count bottle of Replenex extra strength: $40.96

Replenex is indicated for use 3-6 times a day, so one should expect a bottle to last between two weeks and a month. This makes Replenex on the slightly more expensive side of the supplement scale.

To see which supplements are the best at reducing inflammation and improving ease of motion, click here.

Business of Replenex

Replenex is manufactured by Melaleuca, a multi-level marketing program that is similar to Amway and Espial. Their contact information is listed as:

Phone Number: (208) 522-0700

Address: 4609 W 65th S

Idaho Falls, ID 83402

Email: Melaleuca does not make an email address public, however they do have a live chat feature on their website that can be used similarly.

Melaleuca as a company has come under some scrutiny recently. A glance at their Better Business Bureau profile shows that there have been hundreds of formal complaints filed against the company over the last few years. Many of those complaints are regarding the products themselves, either due to ineffectiveness or negative side effects, and many are about the customer service and the business practices of Melaleuca.

The multi-level marketing model of business has been criticized as a pyramid scheme that takes advantage of its clients. Detractors say that there is less focus on making money by selling superior products but instead by profiteering off of members of your own organization.

Melaleuca is currently being sued in several different cases by former Independent Marketing Executives (what they call their sales representatives) who are alleging that the company misrepresents themselves, their products, and their profitability while attempting to coerce prospective IME’s to sign up.

Follow this link to see our experts’ complete list of the most effective over the counter joint supplements on the market today.

Customer Opinions of Replenex

Objective online reviews of Replenex are hard to find. Since Melaleuca controls their distribution and doesn’t allow as many independent retailers to carry their products, true third-party accounts by users are more rare than they are with more traditionally marketed products. There are a number of supplement review sites that have been able to gather opinions of the product, and these are some common themes found in those reviews:

“Smelled awful and gave me headaches. I quit taking it before I noticed if it did anything.”

“I tried taking this for too long – I even reordered once, thinking I just needed to give it a chance. Nope, it just never did anything and I feel dumb for spending so much money.”

In addition to the reviews of the products, there was an inordinate amount of negative feedback directed at the company themselves. There were hundreds of current and former IME’s complaining about their experiences with accounts similar to these:

“I signed up with these guys after a friend convinced me we could make money. Their products were terrible, no one would buy them, and when I tried to get refunds they ignored me and just keep charging me for new products.”

“This company is like the Hotel California – you can sign up, but you can never leave.”


Click here to see which joint health supplements were rated the best at improving flexibility, mobility, and range of motion.

How Does Replenex Compare?
  • Product Name
  • User Rating
  • Good Company Reputation
  • Quality Ingredients
  • Money Back Guarantee
  • Replenex
  • 24/100
Conclusion – Does Replenex Work?

It is difficult to determine if Replenex will be effective for any given consumer. Their ingredient base is so unstudied that it would be irresponsible of our panel of experts to make a definitive assessment either way. They do caution that with unknown supplements there is always a degree of risk, especially in regard to long-term consumption.

There is definitive evidence to say that Melaleuca is not upfront with all of their pricing and purchasing policies, and that consumers are encouraged to read all fine print before getting involved with their program. Research previous users experiences before deciding to commit for yourself.

Our experts recommend Flexitrinol as the most reliably effective joint health supplement on the market today. Flexitrinol uses a proven blend of ingredients to naturally improve joint health and reduce the effects of inflammation. Click here to learn more about what makes Flexitrinol so effective.

3 Responses to Replenex Review

Michael Raleigh says:

I have been using Replenex for two months now and my joints are working much better than before I took it.

Sherrie says:

My husband has used this product for at least 7 years. He swears ny the benefit he gets. Previous, he had pain from golfing. Now he don’t. He has stopped for a while and found after a while the pain returned. He is back using it again with remarkable results.

Nancy Goodenow says:

My daughter was using Replenex for some time. I was having some hip problems, limping, pain. Had x-rays which did show problems. I started taking two relenex a day and within a week, showed improvement. I now do not have the pain and walk without a limp. She swears by it and has found even not taking them for one day she notices a difference. I do not see any problems with it.

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