Tri-Flex GNC: Don’t Buy Before You Read This!

Expert rating: stars-icon     By Natalie K (Senior Reviewer) November 14, 2023       Advertising Disclosure

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 What is it?

Tri-Flex GNC is a joint health tablet that is taken to support flexibility and mobility manufactured by GNC, the well-known supplements and bodybuilding company. Tri-Flex GNC is a daily system that claims to address the root causes of joint pain by supporting the basic biological processes that lead to overall healthier joints. It accomplishes this by stimulating collagen production, reducing inflammation, and contributing general bodily wellness.

Our panel of researchers has determined that Flexitrinol is the top joint health supplement on the market today. Their products consistently outperformed other brands by all significant metrics, and their proprietary blend combines traditional herbs with modern science to create the most effective joint health supplement available today. Flexitrinol users have shown consistent improvement in joint pain, flexibility, and range of motion.

Tri-Flex GNC Ingredients and Side Effects


Hyaluronic Acid Glucosamine Hydrochloride
Chondroitin Sulfate Sodium MSM

 Hyaluronic Acid: A popular additive in more recent joint health supplements. Hyaluronic acid is a lubricant found in humans’ synovial fluid that helps joints, cartilage, and bones all work together pain free. Clinical studies are still determining its effectiveness, though there do not seem to be any major side effects associated with hyaluronic acid. It does come with these consumer warnings, however:

  • There is a risk of allergic reaction to any product that contains hyaluronic acid.
  • There have been some medicinal interactions and those taking prescription blood thinners or heart medication should consult with their physician before use.
  • It is recommended that pregnant or nursing women avoid hyaluronic acid.

Glucosamine Hydrochloride: Also a common additive for joint health supplements, glucosamine is known to stimulate the body’s natural cartilage and synovial fluid manufacturing and repair. Glucosamine is frequently used to combat arthritic conditions and has been shown to aid in overall health and immune functionality. There are few side effects associated with glucosamine, the most serious of which is a potential allergic reaction (though those cases are rare)

Chondroitin Sulfate Sodium: Another one of the more basic additives in joint health products. Usually derived from sharks or cows, chondroitin is used to combat a number of ailments including osteoarthritis, osteoporosis, and heart disease because of its ability to help stimulate the body’s natural collagen production abilities. There are very few known side effects connected to glucosamine consumption, though potential allergic reaction is possible.

MSM: The last main active ingredient listed by GNC for their product is another one of the most-used ingredients in leading joint health supplements. Dimethyl Sulfone is derived from green plants and used in a variety of over the counter treatments for conditions such as osteoarthritis, rheumatoid arthritis, and lowered immune functionality.

Our panel of experts has created a list of the top quality joint health supplements available to consumers over the counter. To see their updated list of products, click here.

Tri-Flex GNC Quality of Ingredients

Individually, there is nothing wrong with the ingredients of Tri-Flex GNC. They are all included on the list of most frequent additives for reputable joint health supplements and have been shown to be highly beneficial for both long- and short-term joint health. Chondroitin and glucosamine especially are found in nearly every effective joint health product because they actually help improve the body’s ability to produce collagen and synovial fluid on its own as opposed to merely treating the symptoms or masking the pain of joint issues, as many other supplements do.

But that’s also the problem with Tri-Flex: every OTC joint supplement on the market that’s at all effective should be utilizing all four of these ingredients – and hopefully several more, too. There is nothing in GNC Tri-Flex that would set it apart from any other halfway decent brand available today

Boswellia extract, boron, and bromelian have all been shown to work well in conjunction with glucosamine, chondroitin, and MSM, increasing the overall effectiveness of any given supplement. GNC has not chosen to include any of those chemicals in their mix.

For a list of the safest and most effective joint health supplements, click here.

The Price and Quality of Tri-Flex GNC

GNC sells Tri-Flex GNC through their website and through their terrestrial locations as well. Generally a consumer should expect to pay:

  • 1 Bottle of 120 caplets (non-members): $37.99
  • 1 Bottle of 120 caplets (members): $29.99

They offer free shipping on orders over $49 dollars and a 10% bonus for signing up for their membership program.

This is a fairly high price for a joint supplement, especially for one with such generic ingredients. There is nothing wrong with Tri Flex’s GNC proprietary blend, but there is also nothing in it that would suggest you should by it over brands that offer more diverse ingredients or better cost efficiency.

For a list of the best value joint health supplements, click here.

Business of Tri-Flex GNC

Tri-Flex GNC is owned and manufactured by GNC, otherwise known as General Nutrition Center. They are one of the better-known supplement stores and can be contacted at:

Phone Number: (559) 297-9078

Address: 1050 Shaw Ave Ste 1003

Clovis, CA 93612

Email: They do not make their e-mail address publically available online, however they do have a customer contact form on their website.

It should be noted that there are currently several pending lawsuits against GNC based on both their ingredients and on the advertising claims that they’ve made. One suit alleges that GNC knew that their products contained ingredients that had been banned by the FDA and another claims that GNC made false and unprovable claims about their products effectiveness and safety. Both are currently in litigation.

Click here to find the top supplements on the market today for joint health, flexibility, and mobility.

Customer Opinions of Tri-Flex GNC

Most online reviews are mildly positive, which is to be expected given Tri-Flex GNC’s ingredients. There were some more negative comments that could be found including these:

“One star – didn’t help my arthritis at all.”

“When I got my pills they were surprisingly close to the expiration date, and some were moldy.”

“Used it for a couple months, then switched back to my old supplements when I started experiencing pain again.”

The most frequent negative reviews had to do with the product not working, however there were a strange amount of individuals like the one above that received what seemed like old pills. There were numerous reports of pills being received close to their expiration date, despite the fact that at the time of manufacture most of those dates are set years in the future. There were also reports of pills being dusty, moldy, or tasting “stale” or “off.”

For a list of the most effective joint pain relief products on the market today, click here.

How Does Tri-Flex GNC Compare?
  • Product Name
  • User Rating
  • Good Company Reputation
  • Quality Ingredients
  • Money Back Guarantee
  • Tri-Flex GNC
  • 82/100
Conclusion – Does Tri-Flex GNC Work?

Going by the reviews online, it is hard to say if Tri-Flex GNC will be effective for any given consumer. Some individuals see relief, others do not. It is probably true that you could find similar formulas for less money, and that there are more complex recipes out there that may be more effective. Tri-Flex GNC is not the worst supplement out there, but it certainly isn’t the best either.

Our experts have concluded that the best joint health supplement currently on the market is Flexitrinol. It is an OTC flexibility and mobility aid that has been clinically proven to be effective in relieving joint pain. Click here to learn more about Flexitrinol and its benefits.

3 Responses to Tri-Flex GNC: Don’t Buy Before You Read This!

Dr. Donald Chuah says:

My Triplex has black spots in the surface and also inside when cut into half. the expiry date is 11/18. Is it moldy? Bought in the Us.

Theresa McNeely says:

I have taken TriFlex for years, I am 81 years old and have recommended it to anyone. However I recently bought the Fast Acting TriFlex and began having aches in my thighs and hips. I have had similar leg problems especially with the HGH suppement they advertise on TV. I could hardly walk after 2 months on that. Is there anything different in the fast acting pills that would react on me that way. I am certainly going back to the regular Triflex.

Shaheena says:

How can I use triplex as I bought in quantity for my mum but she leave us Inow I still hv some flacon full. I want to know who can use it what age. Can we use it as prevention

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