USP Labs Super Cissus RX Review: Don’t Buy Before You Read This!

Expert rating: stars-icon     By Natalie K (Senior Reviewer) November 14, 2023       Advertising Disclosure

User Rating:


stars-icon + -
What is it?

USP Labs Super Cissus RX is an over the counter herbal supplement taken for joint support. It is a daily capsule system that bills itself as being chondroiten- and stimulant-free. Their website refrains from making specific claims about results, as many other supplement companies do, and instead they choose to focus on their ingredients.

After exhaustive study, our panel of nutrition experts has concluded that Flexitrinol is currently the most effective OTC joint health product available at this time. Their proprietary blend of top quality ingredients has proven to be the best value for patients seeking relief from stiffness and joint pain. Flexitrinol also increases flexibility, range of motion, and stimulates collagen production for long term health.

Super Cissus RX and Side Effects


Cissus Quadrangularis Extract Gelatin
Magnesium Stearate Silicone Dioxide

 Cissus Quadrangularis Extract: The main active ingredient in Super Cissus RX. CQ is a derivative of an African succulent vine and a traditional component of many Ayurvedic medicinal recipes.

Western medicine has been slower to start using CQ and there is relatively little clinical data available to assess its quality one way or the other, though it has been used in the treatment of many ailments including:

  • Heart Disease.
  • High Cholesterol.

It has been shown to be POSSIBLY SAFE for short-term usage but very little is known about its long-term impact on the body. Side effects are rare but they may include:

  • Gastro-Intestinal issues such as nausea, diarrhea, and flatulence.
  • Dry mouth.

Gelatin: A protein usually derived from the skin of pigs or cows. Gelatin is a popular choice in many joint health supplements because it contains collagen, one of the major building blocks of your body’s cartilage.

The problem with that is that ingesting collagen means that it enters the stomach where it is further broken down, and there is little evidence to suggest that it ever actually gets to the joint tissue. There are few side effects associated with gelatin, however excessive consumption has been shown to lead to:

  • Upset stomach.
  • Allergic reactions.

Magnesium Stearate: A lubricating compound made of stearic acid and magnesium ions. Usually used in supplements and vitamins to keep them from sticking together and currently found in up to 95% of all supplement capsules. It is thought to be safe in small doses.

Silicon Dioxide: A mineral used in many medicinal supplements, not to be confused with silicone, the plastic-like material. Silicon is thought to have applications for a number of conditions including:

  • Alzheimer’s Disease.
  • Skin health.
  • Hair and nail quality.

This is a relatively small ingredient profile mostly centered around the healing properties of the Cissus Quadrangularis Extract. There seem to be few acutely dangerous additives in their mix, though the lack of chemical diversity may impact its effectiveness for some users.

Click here for a list of the safest, most effective joint health supplements on the market today.

USP LabsnSuper Cissus RX Quality of Ingredients

USP Labs Super Cissus RX relies very heavily on a single ingredient for its effects, and that ingredient is sorely lacking in scientific research that justifies its medicinal value.

Many of the modern “super-ingredients” used in the most popular and effective joint health products will include products like glucosamine, chondroiten, MSM, boswellia, or boron, but none of those are found anywhere in USP Labs Super Cissus RX.

Instead, their advertising is actually proud of the fact that they do not contain some of these ingredients. That is certainly helpful for anyone with a chondroiten allergy, however other consumers may wish they had a product that utilized more proven joint health products.

For a list of the top-rated joint health supplements according to our experts, click here.

The Price and Quality of USP Labs Super Cissus RX

USP Labs Super Cissus RX is available from a number of online retailers, usually for about 24.99 per bottle of 150 capsules – what they describe a s 5-week supply (although their website currently lists it as out of stock).

This certainly makes USP Labs Super Cissus RX one of the more affordable joint health products available over the counter. This low price is probably due to the simplicity of the recipe and lack of other additives.

It should also be noted that despite the “RX” in the title of the supplement it is not available by prescription, nor is it endorsed by the FDA or any medical bodies.

To see a list of the most proven and effective joint health supplements, click here.

Business of USP Labs Super Cissus RX

USP Labs Super Cissus RX is manufactured by USP Labs, Inc., a distributor of several different brands of health and wellness products. They can be contacted at:

Phone Number: (800) 890-3067

Address: USP Labs does not make a physical address available online.

Email: USP Labs does not make an e-mail address available online, however they do have a comment form on their website that messages can be sent through.

USP Labs is not accredited by the Better Business Bureau, and there are a number of outstanding formal complaints against the company. One consumer is in the process of pursuing legal action against the company based on adverse effects they experienced after taking one of their products.

Click here for a list of the joint health supplements that our experts have determined are the most effective.

Customer Opinions of USP Labs Super Cissus RX

There are a number of differing opinions on the effectiveness of USP Labs Super Cissus RX that can be found online. A number of supplement review sites have given it one- and two-star scores, and there are quite a few nasty customer responses that can be found on consumer feedback sites. A sample of customer reviews includes sentiments like:

“I have serious shoulder and back issues and this did little to help provide relief.”

“I may have seen some improvements, but if so they have been pretty minor.”

“I experienced a major health issue after taking Super Cissus RX for 45 days; I immediately stopped taking it and I’m still recovering.”

The majority of positive reviews were found on supplement retailer websites, while a majority of the negative reviews came from outside watchdog sites.

For a list of the best joint health supplements from the most trustworthy manufacturers, click here.

How Does USP Labs Super Cissus RX Compare?
  • Product Name
  • User Rating
  • Good Company Reputation
  • Quality Ingredients
  • Money Back Guarantee
  • USP Labs Super Cissus RX
  • 36/100
Conclusion – Does USP Labs Super Cissus RX Work?

On USP Labs Super Cissus RX’s website they make very few specific claims about what their product does, offering only that it helps with “joint support.” Given how vague that statement is it’s hard to say that USP Labs Super Cissus RX doesn’t do that, however it is also hard to say that it actually does do anything specifically.

USP Labs Super Cissus RX is lacking all of the most common and effective ingredients for fighting joint pain and improving overall joint health. MSM, chondroiten, glucosamine – none of these potent anti-inflammatory, pro-collagen nutrients can be found in their proprietary blend.

Ordinarily our experts would recommend a “try it and see” approach, however due to the reports of major health issues and the lack of clinical data surrounding the medical uses of Cissus Quadrangularis they cannot recommend even that at this time.

Our experts recommend instead Flexitrinol – the top rated supplement in their 2024 survey. Flexitrinol includes MSM, chondroiten, glucosamine, boswellia, boron, and many other proven additives for joint health and nutrition. Flexitrinol scored the best on a number of metrics to become our panels number one recommended joint health supplement.

One Response to USP Labs Super Cissus RX Review


I use this stuff for years, not because it makes my joints better(bit it does when using condroitin ,MSN,and Glucosamine). HERE IS WHAT IT DOES=== very good anti cortizol control. You know the “stress hormone” that causes imflamation, and a laundry list of other crap that zaps the body in eye ball popping ways. I have years of wear from gym and tons a day of steel tossed up to an eight foot high hopper for 37yrs. Now near 69yrs.old. Trust me when you get older your hormone imbalance only becomes more accute. A fine tuned athelete knows what less Cortisol means!

Leave a Reply

Your email address will not be published. Required fields are marked *