Mendamine 25 Review 2024 [WARNING]: Does It Really Work?

Expert rating: stars-icon     By Natalie K (Senior Reviewer) October 13, 2023       Advertising Disclosure

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Mendamine 25 is a joint health supplement intended to support aging bodies suffering from joint tissue loss. Overall joint health improvement is claimed, as well as the ability to reduce pain and the risk for developing osteoarthritis.

Over 25 ingredients are used, many of which are common joint health ingredients. This is intended to reduce inflammation and support bone health in particular.  Different dosing strengths are advised depending on the amount of support needed. Overall Flexitrinol was our top pick for joint health support. This supplement was favorited by users as well, who were able to notice improvements in their range of motion and flexibility. Review these testimonials and see what’s inside of this top rated joint health supplement by clicking here.


Added to this is:

Beta-Carotene Ascorbic Acid Cholecalciferol d-Alpha Tocopheryl Acetate Thiamin HCI
Riboflavin Niacinamide Pyridoxine HCI Cyanocobalamin Magnesium Oxide
Zinc Glycinate Chelate Manganese Sulfate Chromium Nicotinate Glycinate Chelate Bioperine Boron
Boswellia Serrata Phytosterol Complex Chondroitin Sulfate Glucosamine Sulfate L-Histidine
Hyaluronic Acid L-Histidine Hyaluronic Acid MSM Fish Cartilage
Green Lipped Mussel Powder Silicon Dioxide Vegetable Stearic Acid Aqueous Film Coating Magnesium Stearate
Croscarmellose Sodium Microcrystalline Cellulose

Zinc Glycinate Chelate: A specially formulated version of the mineral Zinc that is used to help support normal tissue growth, and when chelated it enters the bloodstream more efficiently.

Click this link to find a list of the most highly regarded joint health supplements.

Boswellia Serrata: Anti-inflammatory tree extract that is most commonly used in Ayurvedic medicine. It’s used also to help treat arthritis related symptoms by reducing inflammation.

Phytosterol Complex: A blend of different naturally found compounds extracted from plants. It is used most commonly to help reduce cholesterol. The official Mendamine 25 website shows that this is derived largely if not all extracted from soy.

 L-Histidine: Amino acid that is supplemented with in order to help treat rheumatoid arthritis. It helps to regulate many metabolic functions within the human body.

Bioperine: Patented black pepper extract which does not have a direct impact on joint health, but it does help support bioavailability. This makes the other ingredients more easily absorbed and sued by the body, so you can get the most impact from it.

Hyaluronic Acid: This is natural found within the body, in particular within the joint and eyes. It is used to help treat osteoarthritis, by improving the cushion that surrounds joints.

Chondroitin Sulfate: A staple joint health ingredient which is standard to many other related supplements. This is used to help support joint health by reduce discomfort and pain.

Green Lipped Mussel Powder: This seafood is commonly added to joint health supplements since it is rich fatty acids the body can use to lower inflammation. Some side effect can result from normal supplementation such as:

  • Liver issues, diarrhea, and gas.

Check out our best of list to discover what joint health supplements were the best of this year.


There is a wide array of several ingredients which can reduce inflammation and potentially improve joint health over tine. A questionable issue is that you have to take a total of 6 tablets and many of the vitamins and minerals are in a minimum of 200% of the daily serving.

Because this is such a significant amount it raises the question as to why would someone need more than 100% of the daily value of these additives. Excess amounts of vitamins and minerals can also be potentially unhealthy, since the body has to filter a lot of this out to prevent overconsumption.

Click here to get a detailed insight into the years very best joint health supplements.


When purchased directly from the official website a 10 tablet bottle sells for $22.37. This is a 60 day supply when used for average strength, but for users who need extra support the company does advise to take 6 pills daily, which amounts to a 30 day supply.

Some may not find it comfortable to have to take so many pills in one day. There’s also the unresolved issue of the heavy use of vitamins and minerals. It would be likely that some of this would be filtered out, since the human body cannot process this much of any nutrient at once.

Some of the ingredients such as the fish extract and green lipped mussel must be taken from a clean source, since excess amounts of this can be damaging to the body. This can occur because of the waters which these kinds of seafood’s are extracted from, if they contain heavy metals it can potentially cause mercury or lead poisoning.

Check out the year’s top rated joint health pills that our review team noted had the best customer reviews.


The company is known as DrFormulas and to contact them they offer a mailing address and phone number:

Phone Number: (888) 406-6499

Address: 5622 Buckingham Dr.

Huntington Beach, CA 92649

Email: A contact form is offered.

They make their products in a facility approved by the FDA, so this limits the chances of contaminations or dosing issues.

A 60 day return window is offered only if purchased direct, and if the bottle is returned.

Neither the original company new nor the new one have any listing on any watchdog groups such as the Better Business Bureau. There doesn’t seem to be any reason to believe that the company is not reputable however.

We’ve compiled a full review of several joint health supplements and in this search have identified the top 10 best.


Here are some notable reviews of this supplement:

“I noticed some changes to the way I felt. It helped reduce my pain and it lead to a day and night difference”

“My joint pain is the same I took it as directed but it still failed to do anything for me”

“Not a complete fix but it did help me a bit and I was able to reduce my pain. I do have to take the full amount though so there’s that”

“My husband took this and he has a lot of physical work to do so he would know better than anyone else. It helped reduce his aches and pains by a wide margin”

As expected from the many joint health ingredients used, this supplement ended up producing notable improvements. There were a handful of customers who did say they did not notice any changes, but this was rated and not the majority. has tallied up the score and about 18% off the 376 reviews are from 4 starts out of 5, and the majority 68% is from 5 starts review. So overall consumers did say they enjoyed taking Mendamine 25.

One interesting concern a customer had was that the ingredients have changed many times. Because of this constant shift in ingredients it’s not easy to determine if consumers are commented on the current formula, and there is no way to know for certain why they have done so many changes to their formula. This lack of consistency prevents potential customers from knowing for certain if what they are using is as it is described.

Review the best of joint health supplements list to see which brands were favorited by consumers, and to see which offer the best ingredients.

How Does Mendamine 25 Compare?
  • Product Name
  • User Rating
  • Good Company Reputation
  • Quality Ingredients
  • Money Back Guarantee
  • Mendamine 25
  • 40/100

Judging from the ingredients used it will produce some benefits. The concern is that the overuse of vitamins and minerals can be potentially damaging long-term. The human body is not built do take an excess of 200% of the daily value of certain ingredients. This can lead to some damaging side effects since the body has to filter it out, and when combined together it can be even more difficult to have it all filtered out. Over time this can lead to some issues to overall health, and it’s unclear why the creators decided to add an excess of these nutrients. You also have to take a lot of pills at 6 a day in order to get the maximum about of benefits.

Our favorited supplement for joint health is the all-natural brand known as Flexitrinol. It has a carefully selected batch of ingredients added at an optimal amount to help support joint health over time, and on the short term. Many consumers have mentioned that they were able to notice great improvements in their pain, inflammation, and overall flexibility. Consistently there was a vast improvement in overall joint health and consumers said it was easy to take.

The makers also produce all the ingredients in a facility which is approved by the FDA, and GMP certified. This helps to establish a consistent quality, and it leaves no doubt that there are routine inspections. Flexitrinol testimonials are offered on their official website; click here to see what’s inside and how it can help improve your joint health.


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