Nucific BIO X4 Review (UPDATED 2021): Don't Buy Before You Read This!

Expert rating: stars-icon     By Richard (Senior Reviewer) September 22, 2020       Advertising Disclosure

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Nucific BIO X4 is a digestive health and weight loss supplement made to provide multiple health benefits. These claimed effects are made possible with the use of a digestive enzyme blend, prebiotic blend, a weight management blend and finally a hunger control blend.

Over 4 billion forms of healthy bacteria are packed into each capsule, with a total of 12 billion with daily supplementation.  The intended benefit of this is maximum absorption of each and every nutrient you eat. It’s also made to improve existing digestive health so your immune health is improved. For weight loss they add both a metabolism booster and an appetite suppressant.

After much review of all the available weight loss supplements, our experts were most impressed by Sletrokor. It offers users a natural blend of ingredients which can assist in efficient and lasting weight loss results. Find out for yourself what Sletrokor can offer for weight loss by looking at their official website.


A supplements facts list is provided and it reveals:

L. Acidophilus L. Rhamnosus L.Plantarum B. Lactis B. Animalis
Amylase (from Aspergilus Oryzae) Bromelain Lipase Green Tea Extract (50% EGCG) Slimaluma (Caralluma Fimbriata Extract)
Vegetable Cellulose Microcrystalline Cellulose Stearic Acid Silica

Acidophilus: One of the most common forms of bacteria that is also found naturally in the human gut and mouth. It’s often added to yogurt, and it can help turn sugar into lactic acid.

Caution must be exercised when used in higher amounts as it raises the risk for potential passage into the blood stream, which can be extremely damaging. Some typical effects from this include bowel syndrome, immune system issues, and cardiac valve disorder.

Studies on its ability to support either weight loss or to prevent indigestion have been mixed, and it’s not conclusive enough to determine either way.

Rhamnosus: Another species of bacteria used in dairy products which can survive the digestive process, allowing itself to be used by the digestive tract.

It’s often recommended to avoid this if one has a compromised immune system, since it can lead to some issues. Typically elderly, pregnant, or young users are advised not to supplement with it.

L.Plantarum: You’ll often find this in a lot of fermented foods such as kimchi, sauerkraut, sourdough, and different cheeses. It has antioxidant properties and it can even been used to reduce intestinal gas.

Lactis: Bifidobacteria as its known is naturally within the human intestine. It will often be added to supplements in order to improve the immune system, and to prevent digestive related issues. In food form it will most often be used within cheese and yogurt.

While likely safe it can potentially cause unwanted symptoms:

  • Gas, bloating, and intestinal pain.

Our review team has crafted a list which offers the best in weight loss supplements.

Amylase (from Aspergilus Oryzae): Derived from a species of mold, Amylase is an enzyme that is made by both the pancreas and it is found in saliva. The reason the body produces it is to help make the digestion of carbohydrates easier.  By causing this process to happen it gives the body a quick energy source by turning starches into usable sugar.

Amylase is most commonly supplemented when there is damage or a blockage in the body. Otherwise it’s not necessary to use it.

Bromelain: A popular enzyme extracted from pineapples. Bromelain has been used for many different purposes including:

  • Reduction of inflammation, improved arthritis symptoms, prevention of pain, reduction of heart burn, nasal decongestion and the breakdown of protein.

Some side effects are possible including:

  • Allergies, intestinal discomfort, and diarrhea.

Promising claims are made about its ability to support fat loss, but it’s still inconclusive.

Lipase: Enzyme which makes it easier for fats to be used as a source of energy. They are essential for proper digestion, and it is naturally produced by the stomach, pancreas, and mouth.

Lipase often does not require any additional supplementation unless there is an underlying medical condition such as celiac disease or Crohn’s disease, according to the University of Maryland Medical Center.

Side effects may result from improper use such as:

  • Upset stomach, nausea, and complications within users who have certain conditions.

Green Tea Extract (50% EGCG): Slightly dried plant that is commonly used as a tea, this is rich in antioxidants and it can improve the immune system. This version has a certain amount of Epigallocatechin gallate, which is referred to as a catechin, a specific kind of antioxidant.

The reason why EGCG is added is because of studies which claim it can result in lowered cholesterol and body fat. Unfortunately the FDA has advised companies to stop making health benefit claims since it is not yet proven in sufficient studies.

Determining if it can actually produce fat loss is more than likely to come from the added caffeine in green tea. It’s not clear if Nucific BIO X4 has any added caffeine, but any metabolism effects are likely to be minor. also says that any fat loss is:

“dependent on being caffeine naïve”

This implies that if fat loss is the goal, then it’s important to know for certain what the caffeine content is, and this would also require cycling. Caffeine will only produce metabolism boosting effects for a short period, and after this time frame the body will adjust causing what is referred to as a tolerance. Excess caffeine however can potentially lead to side effects.

Slimaluma (Caralluma Fimbriata Extract): Patented by the Gencor company, this offers standardized version of Caralluma Fimbriata. Caralluma Fimbriata has been used in India as a “famine” food, which can suppress appetite and thereby regulate weight.

Since it is patented it has been studied and it is organic, kosher, and was granted GRAS status by the FDA. This ensures that it is likely to be safe when used as directed.

Determining if Caralluma Fimbriata can actually lead to weight loss results is difficult due to the amount of preliminary evidence. More 3rd party studies are therefore required before determining if it can actually lead to weight loss.

There are also some potential side effects including:

  • Constipation, upset stomach, and intestinal gas.

Our compiled list features the best weight loss supplements reviewed this year.

EDITOR’S TIP: Combine this supplement with a proven fat burner such as Sletrokor for better results.


The good thing about Nucific BIO X4 is that it is all-natural. The green tea extract can be healthy, but whether or not it can produce reliable weight loss results remains to be seen. The same can be said about Caralluma Fimbriata, since there are insufficient independent 3rd party studies.

This leaves the prebiotic and digestive enzyme blend. Both can be helpful but its unknown if it’s processed in a way to keep it potent.  12 billion strains of bacteria sounds impressive but if it’s not actually all there by the time you supplement with it, then it’s far less valuable.

After much analysis our review team was able to produce a list showcasing the best weight loss supplements.


Direct sales are offered at $29 per bottle. When taken as directed with 3 pills a day, this lasts 30 days.  You take each pill before a meal, and this is to aid the digestive process.

The FAQ section advises to take it for a 30 day period minimum to see effects, and it may also require up to 60 days of daily use. They do advise to:

  • Avoid excess carbohydrates and sweets. 
  • Commence regular exercise.

The reason why it takes about a 2 month period for results is because of the adaptation needed by the digestive system. Gradually Nucific BIO X4 is meant to work with the body and since everybody is different, it can take some time.  No evidence is provided however so as to prove that these claims have been studied.

It is certainly good that they only use natural ingredients without any fillers or artificial additives. The issue is that you just don’t know for certain whether or not the sensitive enzymes and prebiotics would actually remain preserved. They can degrade naturally and become useless if they are not placed inside a capsule which is resistant to heat and stomach acids.

The 4 billion strains of bacteria per serving sounds impressive, but whether or not it is actually preserved is the determining factor on whether or not this supplement can be relied upon. If it doesn’t then all you’re getting is a cheap form of green tea extract and a patented form of appetite suppressing Caralluma Fimbriata, which has mixed studies.

For real weight loss results we recommend reviewing our list of the best weight loss supplements.


The company is known as Nucific and their about us offers their full contact details which are:

Phone Number: (888) 679-5520

Address: 19528 Ventura Blvd. #343

Tarzana, CA 91356

Email: [email protected]

They allow 3rd party tests to ensure the overall quality, and they make it in a US facility.  A 90 day money back return is offered with no questions asked, though they fail to mention the specifics of this policy.

The company’s Better Business Bureau page has a total of 27 complaints. Customers had the following to say:

“Very misleading… purchased a totally different product”

“Will not issue a refund”

“Tried so many times and I’ve not been able to get the right refund”

“Hung up on me”

The most common concerns were that the customer service team was unresponsive, they were unable to get a refund, and they felt mislead by the marketing.

Our top 10 list makes it easy to know what your best options are for weight loss supplements.

EDITOR’S TIP: For the best results, our experts recommend using weight loss pills for at least 3 months. Save your money by buying a few bottles at once.


Overall consumer reviews were mostly pleased with the results, since there was an improvement in digestion. Rarely was there any mention at all about whether or not it produced weight loss results, so it’s impossible to know if it can be relied on for that.

Side effects were a concern since users have experienced:

  • Indigestion, constipation, diarrhea, stomach cramps, and acid reflux.

An interesting concern was that users felt there was no way the bacteria could actually be preserved in these capsules. There was speculation that it would not withstand heat, transportation, and digestion, and that perhaps much of the bacteria would be dead by the time it was used.  It’s unclear if this is true, but it is a valid concern as these strains of bacteria are notoriously sensitive.

Even with a few bottles worth many customers failed to notice any improvements.

We’ve featured the best weight loss supplements inside of the top 10 list featured in this link.

How Does Nucific BIO X4 Compare?
  • Product Name
  • User Rating
  • Has Good Appetite Suppressant
  • Has Only Natural Components
  • Contains No Coffee
  • Nucific BIO X4
  • 51 /100

Overall this supplement seems impressive at face value, but you just don’t know what to expect from it without more information. The added bacteria are possibly ineffective since it’s sensitive to heat and the digestive process. Customers also had mixed reviews due to side effects, no changes in energy or weight loss, and a lack of appetite suppression for many. The most commonly stated benefit was an improvement of digestion; however, there were uncomfortable digestive issues in some. Many failed to list weight loss as a benefit, making it impossible to know if this is reliable as a weight loss supplement.

After reviewing various kinds of weight loss supplements claiming to offer the ultimate solution, the one which was most impressive was Sletrokor. The reason being is that from it outperformed in terms of overall quality and consistency. You can expect a well-rounded formula which customers have said made it easy to realize lasting weight loss benefits.

Users saw a reduction of hunger, improved overall wellness, and less weight on the scales. The makers also help explain in simple terms what it can do to promote noticeable weight loss effects. There’s more information offered on the official website of Sletrokor which we provide when you click this link.

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