Nucific BIO X4 Review (UPDATED 2024): Don’t Buy Before You Read This!

Expert rating: stars-icon     By Natalie K (Senior Reviewer) September 22, 2023       Advertising Disclosure

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Nucific BIO X4 is a digestive health and weight loss supplement made to provide multiple health benefits. These claimed effects are made possible with the use of a digestive enzyme blend, prebiotic blend, a weight management blend and finally a hunger control blend.

Over 4 billion forms of healthy bacteria are packed into each capsule, with a total of 12 billion with daily supplementation.  The intended benefit of this is maximum absorption of each and every nutrient you eat. It’s also made to improve existing digestive health so your immune health is improved. For weight loss they add both a metabolism booster and an appetite suppressant.

After much review of all the available weight loss supplements, our experts were most impressed by Sletrokor. It offers users a natural blend of ingredients which can assist in efficient and lasting weight loss results. Find out for yourself what Sletrokor can offer for weight loss by looking at their official website.


A supplements facts list is provided and it reveals:

L. Acidophilus L. Rhamnosus L.Plantarum B. Lactis B. Animalis
Amylase (from Aspergilus Oryzae) Bromelain Lipase Green Tea Extract (50% EGCG) Slimaluma (Caralluma Fimbriata Extract)
Vegetable Cellulose Microcrystalline Cellulose Stearic Acid Silica

Acidophilus: One of the most common forms of bacteria that is also found naturally in the human gut and mouth. It’s often added to yogurt, and it can help turn sugar into lactic acid.

Caution must be exercised when used in higher amounts as it raises the risk for potential passage into the blood stream, which can be extremely damaging. Some typical effects from this include bowel syndrome, immune system issues, and cardiac valve disorder.

Studies on its ability to support either weight loss or to prevent indigestion have been mixed, and it’s not conclusive enough to determine either way.

Rhamnosus: Another species of bacteria used in dairy products which can survive the digestive process, allowing itself to be used by the digestive tract.

It’s often recommended to avoid this if one has a compromised immune system, since it can lead to some issues. Typically elderly, pregnant, or young users are advised not to supplement with it.

L.Plantarum: You’ll often find this in a lot of fermented foods such as kimchi, sauerkraut, sourdough, and different cheeses. It has antioxidant properties and it can even been used to reduce intestinal gas.

Lactis: Bifidobacteria as its known is naturally within the human intestine. It will often be added to supplements in order to improve the immune system, and to prevent digestive related issues. In food form it will most often be used within cheese and yogurt.

While likely safe it can potentially cause unwanted symptoms:

  • Gas, bloating, and intestinal pain.

Our review team has crafted a list which offers the best in weight loss supplements.

Amylase (from Aspergilus Oryzae): Derived from a species of mold, Amylase is an enzyme that is made by both the pancreas and it is found in saliva. The reason the body produces it is to help make the digestion of carbohydrates easier.  By causing this process to happen it gives the body a quick energy source by turning starches into usable sugar.

Amylase is most commonly supplemented when there is damage or a blockage in the body. Otherwise it’s not necessary to use it.

Bromelain: A popular enzyme extracted from pineapples. Bromelain has been used for many different purposes including:

  • Reduction of inflammation, improved arthritis symptoms, prevention of pain, reduction of heart burn, nasal decongestion and the breakdown of protein.

Some side effects are possible including:

  • Allergies, intestinal discomfort, and diarrhea.

Promising claims are made about its ability to support fat loss, but it’s still inconclusive.

Lipase: Enzyme which makes it easier for fats to be used as a source of energy. They are essential for proper digestion, and it is naturally produced by the stomach, pancreas, and mouth.

Lipase often does not require any additional supplementation unless there is an underlying medical condition such as celiac disease or Crohn’s disease, according to the University of Maryland Medical Center.

Side effects may result from improper use such as:

  • Upset stomach, nausea, and complications within users who have certain conditions.

Green Tea Extract (50% EGCG): Slightly dried plant that is commonly used as a tea, this is rich in antioxidants and it can improve the immune system. This version has a certain amount of Epigallocatechin gallate, which is referred to as a catechin, a specific kind of antioxidant.

The reason why EGCG is added is because of studies which claim it can result in lowered cholesterol and body fat. Unfortunately the FDA has advised companies to stop making health benefit claims since it is not yet proven in sufficient studies.

Determining if it can actually produce fat loss is more than likely to come from the added caffeine in green tea. It’s not clear if Nucific BIO X4 has any added caffeine, but any metabolism effects are likely to be minor. also says that any fat loss is:

“dependent on being caffeine naïve”

This implies that if fat loss is the goal, then it’s important to know for certain what the caffeine content is, and this would also require cycling. Caffeine will only produce metabolism boosting effects for a short period, and after this time frame the body will adjust causing what is referred to as a tolerance. Excess caffeine however can potentially lead to side effects.

Slimaluma (Caralluma Fimbriata Extract): Patented by the Gencor company, this offers standardized version of Caralluma Fimbriata. Caralluma Fimbriata has been used in India as a “famine” food, which can suppress appetite and thereby regulate weight.

Since it is patented it has been studied and it is organic, kosher, and was granted GRAS status by the FDA. This ensures that it is likely to be safe when used as directed.

Determining if Caralluma Fimbriata can actually lead to weight loss results is difficult due to the amount of preliminary evidence. More 3rd party studies are therefore required before determining if it can actually lead to weight loss.

There are also some potential side effects including:

  • Constipation, upset stomach, and intestinal gas.

Our compiled list features the best weight loss supplements reviewed this year.


The good thing about Nucific BIO X4 is that it is all-natural. The green tea extract can be healthy, but whether or not it can produce reliable weight loss results remains to be seen. The same can be said about Caralluma Fimbriata, since there are insufficient independent 3rd party studies.

This leaves the prebiotic and digestive enzyme blend. Both can be helpful but its unknown if it’s processed in a way to keep it potent.  12 billion strains of bacteria sounds impressive but if it’s not actually all there by the time you supplement with it, then it’s far less valuable.

After much analysis our review team was able to produce a list showcasing the best weight loss supplements.


Direct sales are offered at $29 per bottle. When taken as directed with 3 pills a day, this lasts 30 days.  You take each pill before a meal, and this is to aid the digestive process.

The FAQ section advises to take it for a 30 day period minimum to see effects, and it may also require up to 60 days of daily use. They do advise to:

  • Avoid excess carbohydrates and sweets. 
  • Commence regular exercise.

The reason why it takes about a 2 month period for results is because of the adaptation needed by the digestive system. Gradually Nucific BIO X4 is meant to work with the body and since everybody is different, it can take some time.  No evidence is provided however so as to prove that these claims have been studied.

It is certainly good that they only use natural ingredients without any fillers or artificial additives. The issue is that you just don’t know for certain whether or not the sensitive enzymes and prebiotics would actually remain preserved. They can degrade naturally and become useless if they are not placed inside a capsule which is resistant to heat and stomach acids.

The 4 billion strains of bacteria per serving sounds impressive, but whether or not it is actually preserved is the determining factor on whether or not this supplement can be relied upon. If it doesn’t then all you’re getting is a cheap form of green tea extract and a patented form of appetite suppressing Caralluma Fimbriata, which has mixed studies.

For real weight loss results we recommend reviewing our list of the best weight loss supplements.


The company is known as Nucific and their about us offers their full contact details which are:

Phone Number: (888) 679-5520

Address: 19528 Ventura Blvd. #343

Tarzana, CA 91356

Email: [email protected]

They allow 3rd party tests to ensure the overall quality, and they make it in a US facility.  A 90 day money back return is offered with no questions asked, though they fail to mention the specifics of this policy.

The company’s Better Business Bureau page has a total of 27 complaints. Customers had the following to say:

“Very misleading… purchased a totally different product”

“Will not issue a refund”

“Tried so many times and I’ve not been able to get the right refund”

“Hung up on me”

The most common concerns were that the customer service team was unresponsive, they were unable to get a refund, and they felt mislead by the marketing.

Our top 10 list makes it easy to know what your best options are for weight loss supplements.


Overall consumer reviews were mostly pleased with the results, since there was an improvement in digestion. Rarely was there any mention at all about whether or not it produced weight loss results, so it’s impossible to know if it can be relied on for that.

Side effects were a concern since users have experienced:

  • Indigestion, constipation, diarrhea, stomach cramps, and acid reflux.

An interesting concern was that users felt there was no way the bacteria could actually be preserved in these capsules. There was speculation that it would not withstand heat, transportation, and digestion, and that perhaps much of the bacteria would be dead by the time it was used.  It’s unclear if this is true, but it is a valid concern as these strains of bacteria are notoriously sensitive.

Even with a few bottles worth many customers failed to notice any improvements.

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How Does Nucific BIO X4 Compare?
  • Product Name
  • User Rating
  • Has Good Appetite Suppressant
  • Has Only Natural Components
  • Contains No Coffee
  • Nucific BIO X4
  • 51 /100

Overall this supplement seems impressive at face value, but you just don’t know what to expect from it without more information. The added bacteria are possibly ineffective since it’s sensitive to heat and the digestive process. Customers also had mixed reviews due to side effects, no changes in energy or weight loss, and a lack of appetite suppression for many. The most commonly stated benefit was an improvement of digestion; however, there were uncomfortable digestive issues in some. Many failed to list weight loss as a benefit, making it impossible to know if this is reliable as a weight loss supplement.

After reviewing various kinds of weight loss supplements claiming to offer the ultimate solution, the one which was most impressive was Sletrokor. The reason being is that from it outperformed in terms of overall quality and consistency. You can expect a well-rounded formula which customers have said made it easy to realize lasting weight loss benefits.

Users saw a reduction of hunger, improved overall wellness, and less weight on the scales. The makers also help explain in simple terms what it can do to promote noticeable weight loss effects. There’s more information offered on the official website of Sletrokor which we provide when you click this link.

43 Responses to Nucific BIO X4 Review

Anonymous says:

I only wanted to try one bottle but never got total confirmation of order and clicked again stupid non technical me! I would only like tto order 1 bottle please refund me the second bottle back to my account as quickly as you took it! thank you mk

Mark says:

Read carefully folks… the guarantee is vapor ware, non-existant if you actually use the product. The product had zero affect on me and when I asked for a refund WELL WITHIN THE 90 DAYS Nucific refused without the bottles being sent back. REALLY Nucific? Your guarantee is only valid if i DONT use your product? I give you my order number for you to look up to verify I AM YOUR CUSTOMER and you reject the return guarantee because you want me so SHIP bottles back to you AT MY EXPENSE. Not a 100% Money Back guarantee and not honest advertising. Bogus “Guarantee” reads: “If you’re not 100% satisfied with the results, ***send back your order*** within 90 days for a full refund – no questions asked. You will be absolutely amazed at just how quickly your body can change. See the results for yourself…”

There nucific rep also delayed me past the 90 days so guess I’m screwed…Thanks a lot Nucific! Buyer beware!

Jayme Van Auken says:

Thanks, Mark I;ve experienced to many scams and miracle products allready and as fae as refunds nearly impossible and that fine print is the deal breaker if you can even read it. – Jayme Thanks again

Anonymous says:

Thanks for sharing. And thanks to this site for the in-depth review. I was about to try this product until I came across this. Now, I will make hard pass thanks to what I know now.

Thank you.

Arlo says:

This product did not work! Don’t waste your money!

Kim says:

I was doing great losing weight. Thought this might be a good idea to supercharge my loss. No such luck. Constipated, more hungry and stopped losing weight. Going to ask for a refund. Going back to plain old healthy food, water, exercise and calorie reduction.

Sabby says:

Omgosh! I just fell for this bio.x4 nucific! I was having fluid retention and thought it would help? Now I have. Products that they do not back up as money back guareentee?

judy laurin says:

I haven’t received mine yet but after reading reviews I plan to return

Anonymous says:

I am on my second bottle, with zero effect except hair loss…great. I don’t often order online, but after watching the entire video I was convinced this was a good product. Wrong! None of the benefits they claim have materialized. I feel that I got totally sucked in.

Alyson says:

I have developed a rash on my face and neck after about 5 days on the BIOx4. Emailed customer service and waiting to hear back to see if they’ve had similar complaints.

Me says:

OMG I just got my order today, and this is not what I read about and wanted to try, I was lead to understand this product was for digestive, immune system, and energy. I don’t need weight loss due to a chronic illness, and the add I read “on Face Book” should have known! But it hit all the right notes, and so without doing some checking like now………..And so I guess I wasted my money, omg I’m turning into my mom, ordering things that aren’t what they seem!!!

Anonymous says:

So glad I read these reviews how people can constantly rip people off especially when trying to improve their health there’s got to be a way to stop this before it harms someone serious

Earline says:

Thanks for that information about nucific Bio x4 I was going to spend money on some thing that really doesn’t work

Cheryl says:

I have been working n bio X4 and I love it. My digestive system has never been better. I have lost 7 lbs in 45 days and I feel more alive. I also have the urge to exercise more.

Anonymous says:

I ordered, they took my money and not product.

bill Allen says:

After watching the video presented by Dr. (somebody) I ordered 5 bottles; four of which came to $99.00. Before I found this blerb on the internet I was under the impression that this product would do wonders for my body. Now I discover that it is basically for better health (very broad definition). I have taken this product for over a month now and see nothing new or better.
This reminds me of the traveling salesman in his covered wagon selling the “wonder drug” for only $1.00 a bottle.

Jae says:

Thank you for the reviews and the breakdown about the product. After checking this out I’m sure I’ll be leaving my money in my account! It does sound great on the surface but once you did a little deeper I think it’s best for me to just stick with healthy lifestyle choices and exercise! Thanks for the info!

Shawna says:

Same here. This 45 minute video had me convinced. Glad I looked at this and read the truth. 2 1/2 stars??? Yikes!
Now time to watch reviews on the other wiz bang pill recommended here. Sletroker

Maria Hensch says:

Me too so glad I checked everything out b4 ordering seemed convincing and logical. I don’t order anything anymore without checking first…been burnt a few times…no more!!

Anonymous says:

Product didn’t work, gave me a bunch of gas. The return cost me over 12.00. Still waiting on my money back.

larry lonski says:

Stay far away from products that have not been proven. The only effect you will see is cash loss. It is necessary to supplement your body with probiotics/amylase/lipase…. and all the other ingredients per bottle. The only true and effective weight loss is calories in and calories out. Eat less, make appropriate food choices, don’t eat late at night before bedtime and exercise.

Tan D says:

I looked at reviews 2 days after I placed order = realized that some of the ingredients could actually harm my 85 yr old system & its initial effect can be gas & bloating – which is exactly the problem I wanted to cure!! Call to cancel polite sales person said it has shipped tho no email confirm of that – of course already charged. Horrified to find that their guarantee does not include a postage paid return label even if unopened.. In local post office you wait at least 30 mins in line! I ordered 3 bottles… Another example of the power of advertising – seems it can sell anything.

edonowitz says:

BUYER BEWARE: I was really turned off by the continued hard sell to the point of harassment to buy more of this product. As a result, It feels like a total scam. I tried it with reservations and, alas, didn’t notice any difference after 3 months.
Certainly not worth the repeated emails, calls, notices popping up with better and better savings if I bought more bottles….totally exhausting & unprofessional.

Peter says:

I tried out the product. It did not work for me. I sent back the product that was unused for a refund as per their policy. They said they never received the return package. It did arrive, but they either misplaced it or are dishonest. Not a trustworthy company. Sorry do not recommend them or their product.

Bob says:

Has anyone asked what the shelf life of his product is? A year ago I ordered 18 bottles and have 8 bottles left since I do not always take 3 capsules a day. Manufactured date on bottles is Sept 2017. Well, I called customer service today and asked what the shelf life for BIO-X4 is. They told me 1 year from date of manufacture. Has anyone seen this information anywhere on the bottle or in their advertisements? I couldn’t find it. So, technically, the 8 bottles I have now are out of date and cannot be returned because the 90-day guarantee has long expired. Guess I’ll throw them away. Unfortunately, I had already ordered another 18 bottles and they’ve shipped! I was emailed a return form for 6 bottles and will need to use the remaining 12 before they expire (whenever that will be). The moral of this long story: Don’t order more
than you will use in a year! And Nucific, be more upfront about the shelf life! Written on 10/01/2018

Anonymous says:

Yes I have seen it mentioned it the video

Lisa Veal says:

Hi, I love this product! I’m about to order more right now. I take the Bio x 4 and the digestive enzymes. Nucific works better than any other I’ve tried. Anyway, I just wanted to throw that in. Thanks very much!

Mary Gaul says:

I took it for 29 days then suddenly experienced all the significant side effects you mention and more. I was told to go to the ER, because the symptoms suddenly included possible heart problems until I was told the cardiac issue could be okay but told to take further tests to make sure. When released from the hospital I now have to do two abdominal studies, with a cardiac evaluation including an upcoming stress test. In addition, I will be sent for a colonoscopy/ endoscopy. So far my medical professionals have told me that they believe this was due to the supplement. I sent an email to the company telling them of this. Obviously I do not recommend this product

Teresa Nichols says:

This provide gave me a real bad headache n make me vomit, I had stomach issues for days. I do not recommend it.

Anonymous says:

Buyer beware…This does not work do not WASTE your money.

cora says:

I bought 6 bottles of Bio X4 and almost gone now but I still did not get any result but instead I gain more weight. It DID NOT help me to stop my craving, instead I overate more. It DID NOT give me energy or boost my metabolism. It’s all lie and promises!

Anonymous says:

This product does not work i used for 56 days straight!! I even increased and started to take 2 still NOTHING … continued to try since it comes with a 90 day guarantee when i called for the guarantee they said I had to have the empty bottles CRAP after talking to CS I went back to the website i ordered from to see as well as my order page NOWHERE ON THERE DOES IT SAY TO KEEP BOTTLES …

Sue Clauss says:

Once starting Bio x4, I noticed my heart started skipping beats and did not beat normally as if beating simular to heart type murmer. I only took two a day, one at each meal. I took the product for five days. I am very active having no health issues. I have since stopped taking Bio x4.

Mommydearest says:

Didn’t work for me either took three months of it and nothing.

Roberta D Holliday says:

I was tripled billed for this product. I do not know if it worked or not. They seem like a not liget company the way the purchase processing goes.

Teri Farina says:

Well I like it. I have lost 20 pounds since December 2018. I lost it it like a pound or 2 a week. I have a multitude of medical issues and taking about 10 prescriptions. This has not interfered with any of them. My biggest problem is that my stomach is always bloated. Since taking this, rarely ever bloated. I haven’t had a stomach as flat as this in years and years. The appetite suppressant works great for me. I have now downsized to a medium from size large. I very happy with this product.

Daniel DeCosta says:

Absolutely worthless. Did not help with ANY of the claimed weight loss, appetite, digestive improvement claims. Expensive and useless – no results

Daniel DeCosta says:

Absolutely worthless! Did not provide ANY of the benefits listed. Do not waste your money!

Joe France says:

The ordering process is deceptive and basically confusing. I would not deal with these people ever again. The product itself is basically harmless, but does little of what the purveyors claim it can do. Be careful, and buy scientifically proven products from reputable dealers and solid companies who do not over-hype their products. I am not happy with these people.

Brenda Fuselier says:

Some kind of a way i ended up with this product and i didn’t even order it. i was just looking at it on the web site. I am very suspicious of this company.

joseph umali fernandez says:

WELL, I just received my bottle biox4 in the mail yesterday and I just took a pill with my oat meal. not knowing too much about the product; just wanted to address my digestion issue. I don’t want to lose weight, but I don’t want diarrhea. well here goes the first message I will leave for the bio x4.
day 1 / pill one=breakfast

tamara jackson says:

I have taken as directed, and suffered dietary upsets ever since. I want a refund, this is not what I wanted. Dietary upsets are very unpleasant. Please advise regarding refung.

Irene Valentin says:

My husband recently ordered this supplement for both of us to take. We haven’t received it yet, My question is… Does this supplement have any seafood/shellfish additives? I have a severe allergy to both. Please let me know asap

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