Brisdelle Review: Don’t Buy Before You Read This!

Expert rating: stars-icon     By Natalie K (Senior Reviewer) May 5, 2023       Advertising Disclosure

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What is it?

Brisdelle is a non-hormonal prescription drug used to reduce hot flashes and other symptoms of menopause. This drug is aimed at providing relief after four weeks of use.

Brisdelle is the only FDA-approved, non-hormonal medication for hot flashes currently on the market. The product is made from an antidepressant, though Brisdelle is only meant to treat those with menopause, and no other condition.

In looking at a variety of products targeting symptoms of menopause, we’ve learned that Femmetrinol works the best for eliminating hot flashes, night sweats and other uncomfortable or embarrassing afflictions associated with going through this change. Take a look at the all-natural ingredients that make Femmtrinol so effective – click here for more.

Brisdelle Ingredients and Side Effects

The Brisdelle website outlines the key ingredient in this product, which is an SSRI known as, paroxetine. Here’s a look at what you can expect with use:


Paroxetine: Paroxetine belongs to a class of drugs known as selective serotonin reuptake inhibitors (SSRIs), which are generally prescribed as an antidepressant. SSRIs help balance serotonin in the brain, which can improve mood or reduce anxiety in people with varying mental health conditions.

Brisdelle itself is made from paroxetine, as mentioned above, but it’s only indication is for menopausal hot flashes, and is not intended to treat anxiety, depression or any other condition.

  • Side effects may include rash or skin hives, changes in mood, panic attacks, trouble sleeping, bone pain or tenderness, hyperactivity or easy bruising.
  • Additional side effects may include vomiting, nausea, diarrhea, hallucinations and slurred speech.
  • In rarer cases, paroxetine may cause a severe reaction in the nervous system, which includes rigid muscles, sweating, confusion and a racing heart.

Click here for a look at how herbal supplements can help get your hormone levels back on track.

Brisdelle Quality of Ingredients

As Brisdelle is an FDA-approved prescription drug, most users that were prescribed this product shouldn’t have too many problems. The official website mentions that many users felt nauseous throughout the first week of taking this product, though symptoms subsided after that time had elapsed.

It’s worth noting that, this product is not intended to treat anything other than hot flashes, so users with the full range of menopause symptoms may want to look at other products that offer relief from mood swings, fatigue and more.

Brisdelle has rather mixed reviews, so success in using this product likely has a lot to do with the person taking it. Though it’s not intended to treat depression or anxiety, there were a number of people who mentioned that it helped with these conditions, that they weren’t otherwise treating.

Suffering from hot flashes? Here’s a look at the supplements that can best help you deal with menopause.

The Price and Quality of Brisdelle

Brisdelle is available with a prescription only, so users can’t just pick this up online or at their local market. In most cases, insurance should cover the prescription, or at least a portion of it.

According to our findings, Brisdelle is available out of pocket for roughly $200 a month, though the company that makes this product offers some coupons for consumers looking to save on their prescription.

Unfortunately, there are no generic versions of this drug available at this time, so users who don’t have coverage may want to look at a more comprehensive solution for menopause symptoms, or something that comes at a lower cost.

Because this product addresses hot flashes exclusively, it seems as though the price point is rather high.

Take on menopause once and for all – our guide to the best herbs, vitamins and more that can help you become hot flash-free.

Business of Brisdelle

Brisdelle is made by the pharmaceutical company, Sebela Pharmaceuticals International. Their contact information is listed below:

Phone: 844-SEBELA1

Address: 645 Hembree Parkway, Suite I
Roswell, GA 30076

Sebela Pharmaceuticals is a Georgia-based pharmaceutical company that makes eight different drugs distributed and sold in the United States. The company focuses on niche therapeutic markets in different medical spaces—women’s health, dermatology, gastroenterology and more.

The Sebela website looks very clinical and provides a bit of information about each of the drugs they sell, though they don’t go into great detail.

Brisdelle does have a dedicated site, offering vouchers for prescription savings, as well as a rundown on what the product does and what the potential side effects might look like to a user. There’s not much regarding the science behind the product, nor does it explain why Brisdelle does not have any merit as an official anti-depressant—we’re still not sure if there’s a different dosage or processing method, or if it’s simply a branding issue.

Overall, it seems like users can take some solace in the the fact that they are getting an approved drug by a reputable drug company. While it might not be the best solution for treating menopause symptoms beyond hot flashes, we can see how the non-hormonal formula might be appealing.

Customer Opinions of Brisdelle

Brisdelle is a fairly common prescription drug, and as a result, there is a large pool of users who left their feedback for others’ benefit. Here’s a look at what we were able to gather from some of the previous consumers using this product:

“Initially, I really thought Brisdelle was a fantastic product. Then, I immediately started to gain weight; 15 lbs over only three months, and it made it hard to get out of bed before 12pm most days.”

“Brisdelle significantly reduced both the frequency and severity of my night sweats and improved my moods. I like this drug, but it’s expensive.  A friend has seen similar results with Paxil, and it’s cheaper.”

“I eat super healthy and never changed my habits, but after about 7 months of this product, my body decided to bulk up all of a sudden. I’m not getting hot flashes, but I’m really unhappy about the weight.”

“Brisdelle is way too expensive. I’m not sure why they charge so much for this, when it’s just an SSRI. I switched to LexaPro, and am getting good results without the side effects of Brisdelle.”

Brisdelle has a significant amount of critical reviews associated with its use. Most notably, many users raised the point that many people are seeing similar reductions in hot flashes from taking antidepressants, but are able to get these drugs at a much lower cost. If Brisdelle is just a lower dose of Paxil, it doesn’t make sense that they’d be justified in charging more just because of the packaging, marketing or approved indication.

The other issue is, a really significant amount of Brisdelle users cited notable weight gain, even when their other habits did not change. While in some cases, relief may win out over vanity, it might be a hard sell to people, while most likely do not want to gain weight just by taking a daily pill. There’s also the issue of whether customers are comfortable taking a drug that addresses mood disorders—should the consumer have no history of anxiety or depression, there’s the risk of seeing some changes where none was needed.

Click here for an in-depth look at how to treat menopause without all the hormones.

Conclusion – Does Brisdelle Work?

Based on looking at the reviews and the formula of Brisdelle, it’s difficult to say whether this is the best way to treat menopause symptoms. It’s great that users are offered a prescription alternative to hormonal treatments, which naturally many users would like to avoid, but there are some drawbacks.

Reviews for this product were not great. Many people cited that they did receive some benefits, but they also mentioned that they experienced changes in mood or weight gain, or in some cases fatigue or feeling as though they had a hangover. It seems many of the effects of this product were more disruptive than the hot flashes themselves.

Additionally, Brisdelle is only approved for one use—hot flashes, which is not the only symptom of menopause. In a few cases, we came across people who mentioned this helped reduce some mild anxiety and depression, but they didn’t specify whether these conditions were in place prior to menopause, or were a symptom.

Users looking for a solution that addresses issues beyond the hot flashes are better off looking at hormonal treatments, or an herbal supplement that targets the other symptoms as well. The out-of-pocket costs may be a bit too high for a product that only does one thing, but has the potential to cause a number of other problems.

After looking at a range of solutions more closely, we’ve found that Femmetrinol provides the most efficient relief from uncomfortable hot flashes, changing moods and fatigue commonly associated with menopause. This product is made from wild yam, damiana, black cohosh and more, which offer a safer alternative to HRTs.

The makers of Femmetrinol operate according to CGMP standards and work hard to make sure customers receive a product that works and doesn’t come with any adverse effects. Click here to learn more about the benefits of Femmetrinol.


One Response to Brisdelle Review

Sally Gump says:

I was prescribed Brisdelle for hot flashes. I have taken it for about 4 months. I have been so tired. Bone tired. I can not get enough sleep. And I do not sleep well.
My legs get cramps too. Overall, I am tired of this medication and have stopped it.
I now feel rested from sleep, go to work feeling awake, and feel tired in the evening from a full day’s work.
I would rather have hot flashes than take this crap.

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